Recruiting

Imaging Methods

Sponsor:

Memorial Sloan Kettering Cancer Center

Code:

NCT02422550

Conditions

Radiation Therapy

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

MRI or CT

Study Details

Brief summary:

Magnetic resonance imaging (MRI) is currently one of the standard diagnostic imaging methods used to diagnose tumor stage before treatment in the Radiation Oncology Department. It is also used to check responses to radiation after treatment. However, MRI isn't traditionally used in planning for radiation treatment or in checking treated tumor and tissue changes during radiation treatment. The goal is to find out the possible benefits of MRI imaging techniques in these settings of radiation treatment. The research aims are to study the possibility of using devices with new abilities such as the MR-Linac. The MR-Linac combines a radiation treatment machine with a diagnostic MRI scanner. This device will improve the quality of MRI-guided radiation treatment. The MR-Linac has functions that are currently not available in other combined imaging and radiation delivery devices. The MR-Linac does not provide additional imaging capabilities that are not currently available in other imaging devices.

Participating in this study would NOT change the current treatment plans, this will allow the investigators to use the MRI methods in research and future patient care.

Conditions

Radiation Therapy

Study ID

NCT02422550

Start date

Apr 9, 2015

Status verified date

Aug, 2026

Completion date

Apr, 2027

Anticipated

Primary completion date

Apr, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Men and women age 18 or older

Exclusion Criteria:

  • Anyone who would be normally excluded from undergoing an MRI examination as per Memorial Hospital for Cancer and Allied Diseases Screening Questionnaire
  • Participants/volunteers with a pacemaker, aneurysm clip or any other condition that would warrant avoidance of a strong magnetic field
  • Female participants/volunteers who are pregnant or nursing
  • Participants/Volunteers who are unable to comply or complete the MRI exam due to claustrophobia or high levels of anxiety
  • Participants/Volunteers from the vulnerable population, as defined by 45 CFR 46.
  • Participants at higher risk due to age, frailty, or the emergent nature of their condition.

Study Design

Enrollment

937 participants

Anticipated

Interventions and Outcome Measures

Arms

participants undergoing radiation therapy & normal volunteers

Protocol participation will consist of one or more research MRI or CT exams not to exceed 45 minutes.

Interventions

MRI or CT

Participants enrolled on this protocol may undergo multiple MRI or CT examinations periodically over the course of their treatment and follow-up if they are participating in a development project related to tumor response assessment. Volunteers enrolled on this protocol may undergo multiple MRI examinations periodically for studies of reproducibility.

Primary outcome measure

  • evaluate the feasibility of new MRI or CT applications [ Time Frame: 5 years ]

Central Contacts and Locations

Central contacts

Nancy Lee, MD

212-639-3341

Simon Powell, MD

212-639-6072

Locations

Memorial Sloan Kettering Basking Ridge (Consent only)

Recruiting

Basking Ridge, New Jersey, United States, 07920

Contacts

Nancy Lee, MD

212-639-3341

Memorial Sloan Kettering Monmouth (Consent only)

Recruiting

Middletown, New Jersey, United States, 07748

Contacts

Nancy Lee, MD

212-639-3341

Memorial Sloan Kettering Bergen (Consent only )

Recruiting

Montvale, New Jersey, United States, 07645

Contacts

Nancy Lee, MD

212-639-3341

Memorial Sloan Kettering Commack (Consent Only)

Recruiting

Commack, New York, United States, 11725

Contacts

Nancy Lee, MD

212-639-3341

Memorial Sloan Kettering Westchester (Consent only)

Recruiting

Harrison, New York, United States, 10604

Contacts

Nancy Lee, MD

212-639-3341

Memorial Sloan Kettering Cancer Center

Recruiting

New York, New York, United States, 10065

Contacts

Nancy Lee, MD

212-639-3341

Simon Powell, MD

212-639-6072

Principal Investigator:

Nancy Lee, MD

Memorial Sloan Kettering Nassau (Consent only)

Recruiting

Uniondale, New York, United States, 11553

Contacts

Nancy Lee, MD

212-639-3341

More Information

Sponsor

Memorial Sloan Kettering Cancer Center

Last update posted

Aug 11, 2026

Last verified

Aug, 2026

Keywords

  • MRI
  • 15-073
  • participants undergoing radiation therapy

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Memorial Sloan Kettering Cancer Center on 2026-08-11.