Recruiting

High Flow Nasal Cannulas

Sponsor:

Laval University

Code:

NCT02495675

Conditions

Respiratory Failure

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

High flow nasal cannulas

Conventional flow via nasal prongs

Study Details

Brief summary:

This study evaluates the work of breathing among healthy subjects under various conditions of treatment with high flow nasal cannulas. Ten subjects will be included. The design of this study is a cross over of five treatment periods with different flow settings.

Conditions

Respiratory Failure

Study ID

NCT02495675

Start date

Jun, 2015

Status verified date

Jul, 2015

Primary completion date

Oct, 2015

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Healthy subjects
  • Written and informed consent

Exclusion Criteria:

  • Pregnant or breastfeeding women;
  • Subject enrolled in another study excluding co-enrolment;
  • Cardio-vascular or respiratory disease;
  • History of ear nose and throat disease (i.e. surgery, epistaxis, trauma), eso-gastric disease (i.e. esophageal varices, digestive haemorrhage), rheumatologic or neurologic disease possibly interfering with the design of the study;
  • Subject feeling nauseous or under recent fed condition (<1h).

Study Design

Enrollment

10 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

no intervention: No flow

Subjects will be spontaneously breathing in room air with no flow.

experimental: Conventional flow via nasal prongs

Subjects will be breathing with nasal prongs delivering 5 L/min of air (inspired fraction of oxygen: 0.21)

experimental: High flow nasal cannulas 20 L/min

Subjects will be breathing with high flow nasal cannulas delivering 20 L/min with an inspired fraction of oxygen of 0.21.

experimental: High flow nasal cannulas 40 L/min

Subjects will be breathing with high flow nasal cannulas delivering 40 L/min with an inspired fraction of oxygen of 0.21.

experimental: High flow nasal cannulas 60 L/min

Subjects will be breathing with high flow nasal cannulas delivering 60 L/min with an inspired fraction of oxygen of 0.21.

Interventions

High flow nasal cannulas

Comparison of different flow levels

Conventional flow via nasal prongs

Low flow of air delivered through conventional nasal prongs

Primary outcome measure

  • Work of breathing [ Time Frame: 10 minutes ]

Central Contacts and Locations

Central contacts

Mathieu Delorme, PT, MSc

418-656-8711mathieu.delorme.2@ulaval.ca

François Lellouche, MD, PhD

418-656-8711francois.lellouche@criucpq.ulaval.ca

Locations

Centre de Recherche de l'IUCPQ

Recruiting

Québec, Quebec, Canada, G1V4G5

Contacts

François Lellouche, MD, PhD

418-656-8711francois.lellouche@criucpq.ulaval.ca

More Information

Sponsor

Laval University

Last update posted

Jul 13, 2015

Last verified

Jul, 2015

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Laval University on 2015-07-13.