Recruiting
Phase 3

Motor Sparing Knee Block

Sponsor:

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Code:

NCT02540070

Conditions

Osteoarthritis

Knee Arthroplasty

Pain Management

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Interventions

Periarticular

Motor free

Motor free with dex

Ropivacaine

epinephrine

Study Details

Brief summary:

Patients undergoing primary total knee replacement will receive either motor sparing knee block to be performed by anesthesia or periarticular local anesthetic infiltration at the end of surgery by surgeons to assess pain relief as well as capacity to ambulate early. The motor sparing knee block will be performed prior to surgery using ultrasonography and the effect of adding dexmedetomidine, an alpha 2 agonist to the injectate with regards to prolonging the duration of analgesia will be assessed.

Conditions

Osteoarthritis

Knee Arthroplasty

Pain Management

Study ID

NCT02540070

Start date

Aug, 2014

Status verified date

Aug, 2015

Primary completion date

Dec, 2017

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

1. Male and females of 18-85 years of age, scheduled to undergo elective primary total knee arthroplasty.
2. ASA Class I, II, III
3. Good contralateral leg strength

Exclusion Criteria:

1. ASA physical status 4 or above
2. Patients who will need hospitalization due to reason other than the planned surgery.
3. Psychiatric illnesses.
4. Revision knee surgery
5. Narcotic dependency
6. Extraneous sources of chronic pain
7. Inability to provide informed consent.
8. Allergy to any of the drugs used in the study.
9. Contraindications to blocks and multimodal analgesia
10. Wheel chair bound

Study Design

Enrollment

135 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

active comparator: Periarticular

Patients in group 1 will receive periarticular infiltration of LA mixture (100 ml) consisting of 0.3% ropivacaine, 2.5 µg/mL of epinephrine, 10 mg of morphine and 30 mg of ketorolac at the end of surgery and sham injections of saline into the motor sparing knee blocks preoperatively.

experimental: Motor free

Patients in group 2 will receive motor sparing knee blocks with 0.5% ropivacaine with 2.5 µg/mL of epinephrine, 30 mg of ketorolac and 10 mg of morphine with a total local anesthetic volume of 60 ml (300 mg). Sham injections of saline (100 ml) will be injected periarticularly at the end of surgery.

experimental: Motor free with Dex

Patients in group 3 will receive motor sparing knee blocks with 0.5% ropivacaine with 1 µg/Kg of dexmedetomidine, 30 mg of ketorolac and 10 mg of morphine with a total local anesthetic volume of 60 ml (300 mg). Patients in group 3 will receive sham injections of saline (100 ml) periarticularly at the end of surgery.

Interventions

Periarticular

Motor free

Motor free with dex

Ropivacaine

epinephrine

morphine

Ketorolac

Dexmedetomidine

saline

Primary outcome measure

  • Duration of analgesia [ Time Frame: 24 postoperative hour ]

Central Contacts and Locations

Central contacts

Sugantha Ganapathy, FRCPC

519-685-8500Sugantha.Ganapathy@lhsc.on.ca

Locations

University Hospital, London Health Sciences Centre

Recruiting

London, Ontario, Canada, N6A 5A5

Principal Investigator:

Sugantha Ganapathy, FRCPC

More Information

Sponsor

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Last update posted

Nov 15, 2016

Last verified

Aug, 2015

Keywords

  • Adductor canal Block
  • ultrasound
  • periarticular injections
  • Dexmedetomidine

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's on 2016-11-15.