Recruiting

Observational Study

Sponsor:

Columbia University

Code:

NCT02602769

Conditions

Childhood Obesity

Morbid Obesity

Eligibility Criteria

Sex: All

Age: 2 - 20

Healthy Volunteers: Not accepted

Interventions

Transcriptome profiling

Study Details

Brief summary:

Rapid onset Obesity, Hypoventilation, Hypothalamic dysfunction and Autonomic Dysregulation (ROHHAD) is a syndrome named in 2007. The hallmark of the syndrome is the rapid onset obesity and dysregulation of central ventilation. There is little information about the metabolic changes that lead to the rapid onset obesity in these children. The investigators would like to study the metabolic phenotype of these children to understand the disturbances in energy balance that lead to the rapid onset obesity.

Conditions

Childhood Obesity

Morbid Obesity

Study ID

NCT02602769

Start date

Nov, 2015

Status verified date

Oct, 2025

Completion date

Dec, 2026

Anticipated

Primary completion date

Dec, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 2 - 20

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Children with ROHHAD syndrome

Exclusion Criteria:

  • Children with known genetic causes of obesity

Study Design

Enrollment

12 participants

Anticipated

Interventions and Outcome Measures

Arms

Cases of ROHHAD syndrome

Children diagnosed with ROHHAD syndrome during the course of their clinical care by their physicians.

The investigators will perform transcriptome profiling in this group.

Control cohort

Unaffected first degree family members. The investigators will perform transcriptome profiling in this group.

Interventions

Transcriptome profiling

The investigators will obtain blood to extract peripheral mononuclear cells. These cells will be used to generate patient specific hypothalamic cells that will be used for transcriptome profiling.

Primary outcome measure

  • Changes in the transcriptome profile of hypothalamic cells of children with ROHHAD syndrome compared to their unaffected first degree relatives. [ Time Frame: 2 year ]

Central Contacts and Locations

Central contacts

Vidhu Thaker, MD

2128515315vvt2114@cumc.columbia.edu

Locations

Columbia University Irving Medical Center

Recruiting

New York, New York, United States, 10032

Contacts

Vidhu Thaker, MD

212-851-5315vvt2114@cumc.columbia.edu

More Information

Sponsor

Columbia University

Last update posted

Oct 21, 2025

Last verified

Oct, 2025

Keywords

  • Hypoventilation syndrome
  • Hypothalamic dysfunction
  • Autonomic dysregulation
  • Rapid onsey obesity

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Columbia University on 2025-10-21.