Recruiting

Observational Study

Sponsor:

Children's Hospital of Philadelphia

Code:

NCT02708134

Conditions

Cardiac Arrest

Cardiopulmonary Arrest

Eligibility Criteria

Sex: All

Age: 0 - 18

Healthy Volunteers: Not accepted

Study Details

Brief summary:

This is a prospective, observational, multi-center cohort study of pediatric cardiac arrests.

The purpose of the study is to determine the association between chest compression mechanics (rate, depth, flow fraction, compression release) and patient outcomes. In addition, the investigators will determine the association of post cardiac arrest care with patient outcomes.

Conditions

Cardiac Arrest

Cardiopulmonary Arrest

Study ID

NCT02708134

Start date

May 2, 2016

Status verified date

Sep, 2025

Completion date

Jan, 2030

Anticipated

Primary completion date

Jan, 2030

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0 - 18

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Patient received chest compressions for at least 1 minute
  • Patient between gestational age ≥37 weeks and 18 years of age

Exclusion Criteria:

  • Patient on veno-arterial extracorporeal membrane oxygenation (ECMO) therapy at beginning of CPR event

Study Design

Enrollment

7000 participants

Anticipated

Interventions and Outcome Measures

Arms

Pediatric Cardiac Arrests

Pediatric cardiac arrests requiring chest compressions for at least 1 minute managed at clinical centers identified as part of standard clinical operations.

Primary outcome measure

  • Aggregate score composed of American Heart Association (AHA) recommended depth, rate, and chest compression fraction during CPR [ Time Frame: 10 Years ]

Central Contacts and Locations

Central contacts

Vinay Nadkarni, MD, MS

215-590-7430nadkarni@chop.edu

Kathryn Graham

215-590-1859grahamk1@chop.edu

Locations

Kaiser Permanente

Recruiting

Los Angeles, California, United States, 90027

Cedars-Sinai Medical Center

Recruiting

Los Angeles, California, United States, 90048

Valley Children's Hospital

Recruiting

Madera, California, United States, 93636

Chldren's Hospital of Orange County

Recruiting

Orange, California, United States, 92868

Stanford University

Recruiting

Palo Alto, California, United States, 94304

Rady Children's Hospital

Recruiting

San Diego, California, United States, 92123

Children's Colorado

Recruiting

Aurora, Colorado, United States, 80045

Nemours Children's Hospital

Recruiting

Wilmington, Delaware, United States, 19803

Children's Healthcare of Atlanta (CHOA)

Recruiting

Atlanta, Georgia, United States, 30322

Lurie Children's (Children's Hospital of Chicago)

Recruiting

Chicago, Illinois, United States, 60611

University of Chicago, Comer Children's Hospital

Recruiting

Chicago, Illinois, United States, 60637

Riley Hospital for Children

Recruiting

Indianapolis, Indiana, United States, 46202

University of Iowa Stead Family Children's Hospital

Recruiting

Iowa City, Iowa, United States, 52242

Kentucky Children's Hospital

Recruiting

Lexington, Kentucky, United States, 40536

The Johns Hopkins Hospital

Recruiting

Baltimore, Maryland, United States, 21287

Massachusetts General Hospital

Recruiting

Boston, Massachusetts, United States, 02114

Boston Children's

Recruiting

Boston, Massachusetts, United States, 02115

St. Louis Children's Hospital

Recruiting

St Louis, Missouri, United States, 63110

Nebraska Medical Center

Recruiting

Omaha, Nebraska, United States

Dartmouth Hitchcock Medical Center

Recruiting

Lebanon, New Hampshire, United States, 03756

Albany Medical Center

Recruiting

Albany, New York, United States, 12208

Mount Sinai Kravis Children's Hospital

Recruiting

New York, New York, United States, 10029

Morgan Stanley Children's Hospital

Recruiting

New York, New York, United States, 10032

Cohen Children's Medical Center

Recruiting

Queens, New York, United States, 11040

Stony Brook University Hospital

Recruiting

Stony Brook, New York, United States, 11794

Upstate Golisano Children's Hospital

Recruiting

Syracuse, New York, United States, 13210

University of North Carolina

Recruiting

Chapel Hill, North Carolina, United States, 27514

Akron Children's

Recruiting

Akron, Ohio, United States, 44308

Cincinnati Children's Hospital Medical Center

Recruiting

Cincinnati, Ohio, United States, 45229

Nationwide Children's Hospital

Recruiting

Columbus, Ohio, United States, 43205

Children's Hospital of Philadelphia

Recruiting

Philadelphia, Pennsylvania, United States, 19104

Contacts

Vinay Nadkarni, MD, MS

215-590-7430nadkarni@chop.edu

Dell Children's Medical Center

Recruiting

Austin, Texas, United States, 78723

Medical City Children's Hospital

Recruiting

Dallas, Texas, United States, 75230

University of Texas Southwestern

Recruiting

Dallas, Texas, United States, 75390

The Children's Hospital of San Antonio

Recruiting

San Antonio, Texas, United States, 78207

Children's Hospital of Richmond at VCU

Recruiting

Richmond, Virginia, United States, 23219

Seattle Children's Hospital

Recruiting

Seattle, Washington, United States, 98105

Medical College of Wisconsin

Recruiting

Milwaukee, Wisconsin, United States, 53226

Stollery Children's Hospital

Recruiting

Edmonton, Alberta, Canada, T6G 2B7

BC Children's

Recruiting

Vancouver, British Columbia, Canada, V6H 3N1

Alberta Children's

Recruiting

Calgary, Canada, AB T3B

More Information

Sponsor

Children's Hospital of Philadelphia

Last update posted

Oct 2, 2025

Last verified

Sep, 2025

Keywords

  • Chest compressions
  • Cardiopulmonary Resuscitation
  • Pediatric

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by Children's Hospital of Philadelphia on 2025-10-02.