Recruiting

Observational Study

Sponsor:

M.D. Anderson Cancer Center

Code:

NCT02754544

Conditions

Brain Neoplasm

Metastatic Malignant Neoplasm in the Brain

Recurrent Brain Neoplasm

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Direct Electrocortical Stimulation

Electrocorticography

Study Details

Brief summary:

This pilot clinical trial studies how well electrocorticography works in mapping functional brain areas during surgery in patients with brain tumors. Using a larger than the standard mapping grid currently used during brain tumor surgery or a high-definition grid for electrocorticogram brain mapping may help doctors to better identify which areas of the brain are active during specific limb movement and speech during surgery in patients with brain tumors.

Conditions

Brain Neoplasm

Metastatic Malignant Neoplasm in the Brain

Recurrent Brain Neoplasm

Study ID

NCT02754544

Start date

Jul 22, 2016

Status verified date

May, 2026

Completion date

Jan 1, 2028

Anticipated

Primary completion date

Jan 1, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Patients undergoing a tumor resection at the University of Texas M. D. Anderson Cancer Center for a newly diagnosed as well as recurrent primary or metastatic brain tumor located in or adjacent to motor and/or speech brain areas
  • Patients >= 18 years of age
  • Signed informed consent

Exclusion Criteria:

  • Patients with significant neurological motor deficits of the upper extremities, and/or speech deficits, which would preclude them from performing the while awake intra-operative tasks at the discretion of the principal investigator (PI)
  • Patients who have impaired vision and/or hearing and whose performance could affect the study will be excluded at the discretion of the PI

Study Design

Enrollment

75 participants

Anticipated

Intervention Model

Single group

Primary purpose

Diagnostic

Interventions and Outcome Measures

Arms

experimental: Diagnostic (electrocorticography)

Patients undergo tumor resection. During surgery, patients also undergo electrocorticography with either the CorTec high resolution hybrid grid, the PMT high-resolution grid, or the Ad-Tech grid followed by direct electrocortical stimulation.

Interventions

Direct Electrocortical Stimulation

Undergo direct electrocortical stimulation

Electrocorticography

Undergo electrocorticography

Primary outcome measure

  • Electrocorticogram (ECoG) [ Time Frame: Up to 6 months (± 4 weeks) ]

Central Contacts and Locations

Central contacts

Sujit Prabhu, MD

713-792-2400sprabhu@mdanderson.org

Locations

M D Anderson Cancer Center

Recruiting

Houston, Texas, United States, 77030

Contacts

Sujit S. Prabhu

713-792-2400sprabhu@mdanderson.org

Principal Investigator:

Sujit S. Prabhu

More Information

Sponsor

M.D. Anderson Cancer Center

Last update posted

May 20, 2026

Last verified

May, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by M.D. Anderson Cancer Center on 2026-05-20.