Recruiting

Dementia Subtypes

Sponsor:

Washington University School of Medicine

Code:

NCT02763683

Conditions

Parkinsons

Eligibility Criteria

Sex: All

Age: 50+

Healthy Volunteers: Accepted

Interventions

PiB and VAT

Study Details

Brief summary:

The purpose of this study is to use a brain imaging method called Pittsburgh B (PIB) Positron Emission Tomography (PET) and Vesicular Cholinergic Transport (VAT) PET to determine dementia subtypes in patients with Parkinson disease (PD). The ultimate goal of this project is to be able to identify individuals with PD who are at risk of developing dementia, and to distinguish the underlying cause of dementia.

Conditions

Parkinsons

Study ID

NCT02763683

Start date

Jun, 2016

Status verified date

May, 2026

Completion date

Mar, 2030

Anticipated

Primary completion date

Mar, 2030

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 50+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • PD patients must exhibit three of the following cardinal signs: rest tremor, rigidity, bradykinesia, or postural instability; or two of these features with one of the first three displaying asymmetry.

Exclusion Criteria:

  • history of head trauma, major neurological or psychiatric diseases other than Parkinson disease and dementia, e.g. stroke, multiple sclerosis, depression or schizophrenia.
  • severe systemic diseases.
  • inability to lie still for 90 minutes.
  • metallic implants, pacemakers, or any other contraindication to MRI.
  • refusal to consent to brain donation.

Study Design

Enrollment

320 participants

Anticipated

Interventions and Outcome Measures

Arms

Parkinsons Disease

Individuals with Parkinsons Disease

Healthy Controls

Individuals without Parkinsons Disease

Interventions

PiB and VAT

There is no intervention for this study. The PiB and VAT are used during the PET procedures to help to identify any excessive abnormal proteins in the brain.

Primary outcome measure

  • Investigations of Dementia in Parkinsons Disease [ Time Frame: 2030 ]

Central Contacts and Locations

Central contacts

Andrea Slavik, RN, BSN

314 273 8313andreaslavik@wustl.edu

Hailee Domash

314 362 6026domash@wustl.edu

Locations

Washington University in St. Louis

Recruiting

St Louis, Missouri, United States, 63110

Contacts

Susan Donovan, BSN

314-362-6026donovan@wustl.edu

Kaleigh Oberndorfer

314 362 0420kaleigh@wustl.edu

More Information

Sponsor

Washington University School of Medicine

Last update posted

May 8, 2026

Last verified

May, 2026

Keywords

  • Parkinsons Disease
  • PET Imaging
  • PIB
  • VAT
  • Dementia

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Washington University School of Medicine on 2026-05-08.