Recruiting

Observational Study

Sponsor:

University of Minnesota

Code:

NCT02831335

Conditions

Aging

Eligibility Criteria

Sex: All

Age: 21 - 70+

Healthy Volunteers: Accepted

Interventions

MRI

MRI

MRI

Group 4

Study Details

Brief summary:

The purpose of the study is to investigate the associations of the age-related changes in the brain, kidneys and cognitive performance in healthy adults by utilizing multiple anatomic and functional MRI methods along with a battery of cognitive tests.

Conditions

Aging

Study ID

NCT02831335

Start date

Dec 1, 2026

Status verified date

Oct, 2025

Completion date

Dec 31, 2032

Anticipated

Primary completion date

Dec 31, 2030

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 21 - 70+

Healthy Volunteers: Accepted

Inclusion Criteria:

1. English-speaking as primary language
2. No hearing loss or uncorrected vision

Exclusion Criteria:

1. Lacking capacity to consent
2. Having known history of cardiovascular diseases (e.g., clinical stroke)
3. Having acute and chronic obstructive pulmonary disease
4. Having known history of renal diseases (e.g., acute kidney injury)
5. Having known history of cognitive disorder or psychiatric illness
6. Having known history of chemical dependence (e.g., alcohol and narcotics)
7. Being treated with stimulant medications, anticonvulsants, antihypertensives or ß-adrenergic blockers

Study Design

Enrollment

120 participants

Anticipated

Interventions and Outcome Measures

Arms

Group 1

normal 21-35 years old participants

Group 2

normal 36-50 years old participants

Group 3

normal 51-65 years old participants

Group 4

normal 66- 80 years old participants

Interventions

MRI

Perform MRI studies

MRI

Perform MRI studies

MRI

Perform MRI studies

Group 4

Perform MRI studies

Primary outcome measure

  • MRI measured perfusion for each group [ Time Frame: Baseline ]
  • MRI measured vascular reactivity for each group [ Time Frame: Baseline ]
  • Cognitive performance for each group [ Time Frame: Baseline ]

Central Contacts and Locations

Central contacts

Xiufeng Li, Ph.D.

6126258258lixx1607@umn.edu

Locations

Center for Magnetic Resonance Research

Recruiting

Minneapolis, Minnesota, United States, 55455

Contacts

Xiufeng Li, PhD

612-625-8258lixx1607@umn.edu

More Information

Sponsor

University of Minnesota

Last update posted

Oct 15, 2025

Last verified

Oct, 2025

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Minnesota on 2025-10-15.