Recruiting

Cardiac Imaging

Sponsor:

Medical University of South Carolina

Code:

NCT02855554

Conditions

Cardiomyopathy, Myocarditis, Ischemic Heart Disease

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Accepted

Interventions

Cardiac Magnetic Resonance (CMR) imaging techniques

Study Details

Brief summary:

The overall goal of this project is to evaluate the clinical potential of fast quantitative myocardial tissue characterization using recently emerged Cardiac Magnetic Resonance Imaging (CMR) techniques to aid the diagnosis, treatment, and follow up of patients with myocardial diseases, such as ischemic heart disease, cardiomyopathies, and myocarditis.

Conditions

Cardiomyopathy, Myocarditis, Ischemic Heart Disease

Study ID

NCT02855554

Start date

Jun 20, 2014

Status verified date

Nov, 2025

Completion date

Dec, 2026

Anticipated

Primary completion date

Dec, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Subject must be 18-90 years of age.
  • Subject must be previously diagnosed with or suspected to have one of the following conditions.
  • Myocardial ischemia or infarction (group 1)
  • Hypertrophic cardiomyopathy (group 2)
  • Infiltrative cardiomyopathy (group 3)
  • Myocarditis (group 4)
  • Subject must have been referred for a clinically indicated CMR.

Exclusion Criteria:

  • Subject has any implanted device or condition in which an MR scan would be contraindicated.
  • Subject has an acute psychiatric disorder or is cognitively impaired.
  • Subject is using or is dependent on substances of abuse.
  • Subject is unwilling to comply with the requirements of the protocol.
  • Subject has previously entered this study.
  • Subject has an allergy against MRI contrast agents.
  • Subject is in acute unstable condition.

Study Design

Enrollment

240 participants

Anticipated

Intervention Model

Single group

Primary purpose

Diagnostic

Interventions and Outcome Measures

Arms

experimental: Additional 5 minute research MR scan of heart.

The purpose of this is to evaluate new, faster MR scans

Interventions

Cardiac Magnetic Resonance (CMR) imaging techniques

Evaluation of clinical potential of fast quantitative myocardial tissue characterization using recently emerged CMRI techniques to aid the diagnosis, treatment, and follow up of patients with myocardial diseases.

Primary outcome measure

  • Clinical value of fast T1, T2, and T2* mapping of the left ventricle for the assessment of necrosis/scar, edema, and possible intramyocardial hemorrhage in patients with heart disease. [ Time Frame: 2 years ]

Central Contacts and Locations

Central contacts

Mark Ghent, BA

843-876-7148ghent@musc.edu

Jacob Rowe, BA

843-876-4922roweja@musc.edu

Locations

Medical University of South Carolina

Recruiting

Charleston, South Carolina, United States, 29425

Contacts

John Martinez, MS

843-876-7148martjohn@musc.edu

Hunter Gray, BS

843-876-4922grayhu@musc.edu

Principal Investigator:

Akos Varga-Szemes, MD

More Information

Sponsor

Medical University of South Carolina

Last update posted

Nov 5, 2025

Last verified

Nov, 2025

Keywords

  • myocardial tissue characterization

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Medical University of South Carolina on 2025-11-05.