Recruiting

Observational Study

Sponsor:

Cedars-Sinai Medical Center

Code:

NCT02910180

Conditions

Cerebrovascular Diseases

Ischemic Stroke

Repository

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

This study encompasses the maintenance and utilization of a repository of samples from patients with cerebrovascular disease and stroke. The types of tissue taken are blood, cerebrospinal fluid (CSF), tissue, and microdialysis samples. Future analysis of these samples can potentially help investigators to better categorize groups of patients, understand the underlying etiology of these pathologies, identify markers that are associated with favorable or poor outcomes, and track changes that occur during the natural course of the disease or with treatment. This is a prospective observational study which will use samples from such patients to create this library which can be used to explore these questions in the future.

Conditions

Cerebrovascular Diseases

Ischemic Stroke

Repository

Study ID

NCT02910180

Start date

Sep, 2016

Status verified date

Feb, 2023

Completion date

Dec, 2030

Anticipated

Primary completion date

Dec, 2030

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • All patients diagnosed with cerebral vascular disease, regardless of gender, age, ethnicity/race, stage of disease or treatment, are eligible.
  • Expected availability of clinical follow up data
  • Participants must be willing to provide written, informed consent obtained in accordance with institutional and federal guidelines.

Exclusion Criteria:

  • Pregnant women are excluded from the study.

Study Design

Enrollment

900 participants

Anticipated

Interventions and Outcome Measures

Arms

Repository Group

The Repository Group consists of patients which have donated tissue to the repository.

Primary outcome measure

  • Change in modified Rankin Scale (mRS) score [ Time Frame: Baseline, 1 Month, 3 Months, and 6 Months ]
  • Change in NIH Stroke Scale score [ Time Frame: Baseline, 1 Month, 3 Months, and 6 Months ]
  • Change in Barthel Index [ Time Frame: Baseline, 1 Month, 3 Months, and 6 Months ]
  • Change in Montreal Cognitive Assessment test score [ Time Frame: Baseline, 1 Month, 3 Months, and 6 Months ]

Central Contacts and Locations

Central contacts

Nestor R Gonzalez, MD, MSCR

(310) 423-0783Nestor.Gonzalez@cshs.org

Patrick Lyden, MD

(310) 423-0894patrick.lyden@cshs.org

Locations

Cedars-Sinai Medical Center

Recruiting

Los Angeles, California, United States, 90048

Contacts

Nestor R Gonzalez, MD, MSCR

310-423-0783Nestor.Gonzalez@cshs.org

Antoinette Anderson, BS

(310) 423-0783antoinette.anderson@cshs.org

Principal Investigator:

Nestor R Gonzalez, MD, MSCR

More Information

Sponsor

Cedars-Sinai Medical Center

Last update posted

Feb 8, 2023

Last verified

Feb, 2023

Keywords

  • Tissue Repository
  • Cerebrovascular Diseases
  • Stroke
  • Aneurysm
  • Arteriovenous malformation
  • Fistula
  • Intracranial Stenosis
  • Treatment
  • Registry
  • Outcomes

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Cedars-Sinai Medical Center on 2023-02-08.