Recruiting

Observational Study

Sponsor:

University of Pennsylvania

Code:

NCT02967068

Conditions

Aortitis

Cutaneous Vasculitis

Eosinophilic Granulomatosis With Polyangiitis

Giant Cell Arteritis

Granulomatosis With Polyangiitis (Wegener's)

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

The purpose of this study is to collect existing tissue specimens from subjects enrolled in Vasculitis Clinical Research Consortium (VCRC) studies. Analysis of these tissue specimens and linked clinical data collected through VCRC studies may lead to the identification and development of a series of translational research projects. Results of these studies will provide vasculitis researchers with insight into the causes of these diseases and generate new ideas for diagnostic tests and therapies, and will be of great interest to the larger communities of researchers investigating vasculitis and other autoimmune, inflammatory, and vascular diseases.

Conditions

Aortitis

Cutaneous Vasculitis

Eosinophilic Granulomatosis With Polyangiitis

Giant Cell Arteritis

Granulomatosis With Polyangiitis (Wegener's)

Study ID

NCT02967068

Start date

Nov, 2016

Status verified date

Jan, 2026

Completion date

Dec, 2028

Anticipated

Primary completion date

Dec, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • A participant will be deemed eligible for this study if the participant is/was enrolled in another one of the VCRC observational/longitudinal protocols (5502, 5503, 5504, 5505, 5506, 5507, 5563) and/or one of the VCRC interventional studies (5522, 5523, 5526, 5527, or 5562).

Exclusion Criteria:

  • Inability to give informed consent (or their guardians in the case of children) and to sign the consent form.
  • Unwilling to allow the use of their tissue for research.

Study Design

Enrollment

1000 participants

Anticipated

Interventions and Outcome Measures

Primary outcome measure

  • Identify genes that increase the risk of developing vasculitis [ Time Frame: 1 year ]

Central Contacts and Locations

Central contacts

Katie Doyle

Kathryn.Logue@pennmedicine.upenn.edu

Locations

University of Pennsylvania

Recruiting

Philadelphia, Pennsylvania, United States, 19104

Contacts

Katie Doyle

Kathryn.Logue@pennmedicine.upenn.edu

St. Joseph's Healthcare

Recruiting

Hamilton, Ontario, Canada, L8N 3B6

Contacts

Sandra Messier

smessier@stjoes.ca

University of Toronto Mount Sinai Hospital

Recruiting

Toronto, Ontario, Canada, M5G 1X5

Contacts

Nazrana Haq

Nazrana.Haq@sinaihealth.ca

More Information

Sponsor

University of Pennsylvania

Last update posted

Jan 22, 2026

Last verified

Jan, 2026

Keywords

  • CSS
  • EGPA
  • GCA
  • GPA
  • MPA
  • PAN
  • TAK
  • HSP

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by University of Pennsylvania on 2026-01-22.