Recruiting

Genetic Repository

Sponsor:

University of Southern California

Code:

NCT02970045

Conditions

Cancer Risk

Malignant Neoplasm

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Biospecimen Collection

Evaluation of Cancer Risk Factors

Medical Chart Review

Quality-of-Life Assessment

Questionnaire Administration

Study Details

Brief summary:

This research trial collects biological samples and clinical information to create a repository of data from patients with cancer or a predisposition for cancer. Combining genetic information from biological samples and clinical data may lead to more knowledge about why certain cancers respond to treatment and help create more personalized medicine.

Conditions

Cancer Risk

Malignant Neoplasm

Study ID

NCT02970045

Start date

May 2, 2016

Status verified date

Apr, 2026

Completion date

May 2, 2037

Anticipated

Primary completion date

May 2, 2036

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Limited to those patients who are registered for outpatient or inpatient care at University of Southern California (USC) Norris
  • Able to understand and sign the TCCP informed consent, California subject's bill of rights, Health Insurance Portability and Accountability Act (HIPAA), and research authorization form directly or through an authorized representative; the informed consent, subject's bill of rights, HIPAA, and research authorization will be available in both English and Spanish languages

Exclusion Criteria:

  • Individuals who are not registered as patients for outpatient or inpatient care at USC Norris
  • Individuals who are unable to understand or sign the TCCP informed consent, subject's bill of rights, HIPAA, and research authorization in either English or Spanish

Study Design

Enrollment

10000 participants

Anticipated

Interventions and Outcome Measures

Arms

Ancillary-Correlative (biospecimen collection)

Patients undergo collection of blood during a regular care visit or not up to 4 times a year. Extra tissue is collected after removal during standard of care surgery and patients may undergo additional tumor sampling (needle passes) at the time of planned diagnostic biopsies. During bone marrow biopsy, the doctor may reposition the needle up to 3 times, and bone marrow for research will not be collected more than 4 times per year. Patients may undergo additional collection of other biological samples such as saliva, sputum, urine, feces, hair, and surface skin swabs for analysis. Patients also receive surveys or questionnaires to collect demographics, medical, family, and nutritional history, cancer predisposing risk factors, quality of life data, and quality of care data.

Interventions

Biospecimen Collection

Undergo collection of blood, tissue, and other biological samples

Evaluation of Cancer Risk Factors

Ancillary studies

Medical Chart Review

Review of medical chart

Quality-of-Life Assessment

Ancillary studies

Questionnaire Administration

Ancillary studies

Primary outcome measure

  • Number of biospecimen collected for a centralized repository that is linked to clinical data [ Time Frame: Up to 21 years ]

Central Contacts and Locations

Central contacts

Melissa Woodhouse, MHA, MPH

323-865-0489Melissa.woodhouse@med.usc.edu

Locations

USC / Norris Comprehensive Cancer Center

Recruiting

Los Angeles, California, United States, 90033

Contacts

Melissa Woodhouse, MHA, MPH

323-865-0489Melissa.woodhouse@med.usc.edu

Principal Investigator:

Bodour Salhia, PhD

More Information

Sponsor

University of Southern California

Last update posted

Apr 29, 2026

Last verified

Apr, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by University of Southern California on 2026-04-29.