Recruiting

Exercise

Sponsor:

University of British Columbia

Code:

NCT02980796

Conditions

Stroke

Exercise

Rest

Eligibility Criteria

Sex: All

Age: 40 - 70+

Healthy Volunteers: Accepted

Interventions

Exercise

Practice

Study Details

Brief summary:

Participants will complete 11 sessions. These include screening, 5 sessions where exercise or rest (according to group assignment) are paired with practice of a motor task, MRI and Transcranial Magnetic Stimulation (TMS) before and after the intervention will be used to assess neuroplasticity (ability for the brain to reorganize and create new connections).

Conditions

Stroke

Exercise

Rest

Study ID

NCT02980796

Start date

Nov, 2016

Status verified date

Aug, 2017

Completion date

Aug, 2022

Anticipated

Primary completion date

Aug, 2021

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 40 - 70+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Between the ages of 40 - 85
  • Had a stroke at least 12 months ago
  • OR are a healthy adult who does not have a history of neurodegenerative disorders
  • Have the ability to understand English

Exclusion Criteria:

  • Contraindication to brain stimulation (such as a history of seizure or epilepsy)
  • Contraindication to MRI (such as a pacemaker, metal in the eyes / brain or fear of enclosed spaces)
  • Neurodegenerative disorder ( such as Parkinson disease, Alzheimers disease or Multiple Sclerosis)
  • Contraindications to exercise

Study Design

Enrollment

104 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Exercise + practice

Individuals will complete 20 minutes of exercise on a recumbent bicycle before practicing a novel motor task.

active comparator: Rest + practice

Individuals will rest for 20 minutes before practicing a novel motor task. Attention will be controlled during this time.

Interventions

Exercise

Each experimental day participants will complete an acute bout of exercise on a recumbent bike.

Practice

Each experimental day participants will complete a session of skilled motor practice.

Primary outcome measure

  • Change response time during a novel motor task. [ Time Frame: Baseline, After Intervention (2 weeks), 30-day follow-up ]
  • Wolf Motor Function Task Rate [ Time Frame: Baseline, After Intervention (2 weeks), 30-day follow-up ]

Central Contacts and Locations

Central contacts

Asha Toner, BSc

604-828-6303asha.toner@ubc.ca

Jason Neva, PhD

604-827-3369jason.neva@ubc.ca

Locations

University of British Columbia

Recruiting

Vancouver, British Columbia, Canada, V6T 2B5

Contacts

Asha Toner, BSc

604-828-6303asha.toner@ubc.ca

Tamara Koren, MSc

604-822-6886tamara.koren@ubc.ca

More Information

Sponsor

University of British Columbia

Last update posted

Aug 15, 2017

Last verified

Aug, 2017

Keywords

  • Brain
  • MRI
  • Exercise
  • Rehabilitation
  • TMS

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of British Columbia on 2017-08-15.