Recruiting

Resistance ExerciseImproving Blood Pressure and Cardiovascular Risk With Resistance Exercise in African Americans

Sponsor:

University of Illinois at Chicago

Code:

NCT03016351

Conditions

Hypertension

Cardiovascular Diseases

Vascular Diseases

Eligibility Criteria

Sex: All

Age: 18 - 55

Healthy Volunteers: Not accepted

Interventions

Aerobic Training

Resistance Training

Study Details

Brief summary:

After the participant meets all inclusion and exclusion criteria, they will be randomized equally to either the Resistance Training group (RT) or Aerobic Training group (AT). Both groups will participate in an 8 week initial control period, followed by 8 weeks of supervised exercise training, followed by 8 weeks of deconditioning. All participants will undergo the same assessments and procedures one time prior to the initial 8 week control period, and at each of the three periods. Assessments include: blood draws; arterial stiffness testing; ultrasounds of the brachial artery to measure flow-mediated dilation (FMD); gluteal adipose tissue biopsies; exercise testing to determine VO2 max; body composition analysis via DEXA scans; ambulatory blood pressure measurement; diet analysis via food journals; medical history questionnaires; urine analysis for pregnancy; and activity monitoring via accelerometer. Total participation will be 24-26 weeks.

Conditions

Hypertension

Cardiovascular Diseases

Vascular Diseases

Study ID

NCT03016351

Start date

Oct, 2016

Status verified date

Oct, 2022

Completion date

Apr, 2023

Anticipated

Primary completion date

Apr, 2023

Anticipated

Eligibility Criteria

Sex: All

Age: 18 - 55

Healthy Volunteers: Not accepted

Inclusion Criteria:

Sedentary
Body Mass Index of 18.5-40 kg/m²
Born in the United States of either two African-American or two non-Hispanic Caucasian parents
Blood pressure of at least 120/80 mmHg

Exclusion Criteria:

Inability to give informed consent
History of cardiovascular disease or cardiovascular events
Hypertension (systolic >159 mmHg and diastolic >99 mmHg) or on more than one anti-hypertensive medication
Diabetes Type I\& II
Hyperlipidemia, with an LDL-C >159 mg/dL and /or total-C >229 mg/dL
Pregnancy (or intend to become pregnant while participating in study) or nursing
Tobacco use in the past 6 months (including, but not limited to cigarettes, e-cigarettes, hookah, Nicorette, SNUs and chewing tobacco)
Chronic inflammatory disease such as, but not limited to, cancer
Chronic autoimmune diseases such as, but not limited to: lupus, multiple sclerosis, rheumatoid arthritis
Adverse reaction to nitroglycerin
Anemia with a hemoglobin < 8
Head injury within last 6 months
Seizure disorder
Presence of renal disease with a creatinine > 1.5mg/dL
Presence of liver disease with liver enzymes > 3x the upper limits of normal
Currently abusing alcohol or illicit drugs
Unreliability as a study subject, in the opinion of the Investigator
Lidocaine allergy
Amenorrhea
Postmenopausal women

Study Design

Enrollment

140 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Aerobic Training

Participants will undergo a supervised endurance training program in accordance with established guidelines. Each session will be monitored by a physical therapist or exercise physiologist. Sessions will be carried out 3 times per week. During each session, participants will complete a 5 min warm-up followed by 30-45 min of endurance exercise using cycle ergometry. Intensity will be monitored using heart rate monitors during each exercise session, and each participant will receive an exercise prescription with a heart range equivalent to 65-85% of their heart rate max. Participants will be asked to complete 30 min of exercise during each session in week 1, 35 min in week 2 and 40-45 min weeks 3-8 with a 5 min cool down period.

experimental: Resistance Training

Participants will undergo a supervised resistance training program in accordance with established guidelines. Each session will be monitored by a physical therapist or exercise physiologist. Sessions will be carried out 3 times per week, 45 min per session. Muscle strength will be determined once before and once after resistance training by measuring ten repetition maximum (10 RM) for each exercise. Eight exercises (three sets; 8-12 repetitions) will be used on each of the large muscle groups (leg press, leg extension, leg curl, chest press, shoulder extension, biceps curl, abdominal crunch and back extension). In addition, workloads will be progressively increased if the patients can lift the weight more than 12 repetitions.

Interventions

Aerobic Training

After the subject meets all inclusion and exclusion criteria, the subject will be randomized equally to either the ResistanceTraining group (RT) or Aerobic Training group (AT) for weeks 9-16 of the intervention. The participants will be supervised by physical therapists and/or exercise physiologists. Sessions will occur 3 days a week and will be 45 minutes in duration.

Resistance Training

Primary outcome measure

Changes in peripheral and central blood pressure [ Time Frame: Baseline (wk. 0), Pre-training (wk. 8), post- training (wk. 16), post detraining (wk. 24) ]

Central Contacts and Locations

Central contacts

Laurel Thur, MS

312-355-0277 lathur@uic.edu

Shane Phillips, PhD

312-355-0277 shanep@uic.edu

Locations

University of Illinois at Chicago

Recruiting

Chicago, Illinois, United States, 60612

Contacts

Laurel Thur, MS

312-355-0277 lathur@uic.edu

Shane Phillips, PhD

312-355-0277 shanep@uic.edu

Principal Investigator:

Shane Phillips, PhD

More Information

Sponsor

University of Illinois at Chicago

Last update posted

Nov 2, 2022

Last verified

Oct, 2022

Keywords

Hypertension
Exercise
African Americans
Arterial Function
Arterial Stiffness

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by University of Illinois at Chicago on 2022-11-02.