Recruiting

Genetic Testing

Sponsor:

UCLA

Code:

NCT03054584

Conditions

Melanocytic Nevi

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Collecting Nevi

Study Details

Brief summary:

The objective of this protocol is to further elucidate the genetic mutations that drive melanocytic nevi (benign melanocytic neoplasms, moles). This will be performed by whole genome, whole exome, or targeted sequencing of de-identified specimens.

Herein, the investigators plan to isolate DNA from de-identified skin biopsy specimens and blood samples:

1. From melanocytic nevi collected by skin biopsy (a shave or punch biopsy). A part of the tissue will be submitted for routine diagnostic dermatopathology and investigational histomorphologic and immunohistochemical analysis.
2. From corresponding normal tissue (blood). DNA isolated from blood will be used as a normal control when analyzing sequencing data to identify somatic mutations in lesional tissue.

Conditions

Melanocytic Nevi

Study ID

NCT03054584

Start date

Jun 26, 2017

Status verified date

Sep, 2025

Completion date

Jun, 2028

Anticipated

Primary completion date

Jun, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion criteria:

  • Male or female subjects that are 18 years or older
  • Subjects with melanocytic nevi\\

Exclusion criteria:

  • Patients less than 18 years of age
  • Patients without melanocytic nevi
  • Patients with a bleeding disorder or are taking anticoagulation medication

Study Design

Enrollment

50 participants

Anticipated

Interventions and Outcome Measures

Interventions

Collecting Nevi

Will be collecting Nevi and completing a DNA analysis, no intervention will be made.

Primary outcome measure

  • Genome Wide Mutation Analysis [ Time Frame: Feb 2017 - December 2018 ]

Central Contacts and Locations

Central contacts

Maija Kiuru, MD

916-734-0591mkiuru@ucdavis.edu

John Robb

916-551-2636jmrobb@ucdavis.edu

Locations

University of California-Davis, Department of Dermatology

Recruiting

Sacramento, California, United States, 95816

Contacts

John Robb

916-551-2636jmrobb@ucdavis.edu

More Information

Sponsor

University of California, Davis

Last update posted

Sep 18, 2025

Last verified

Sep, 2025

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of California, Davis on 2025-09-18.