Recruiting

Cognitive Training

Sponsor:

University of Alabama at Birmingham

Code:

NCT03094026

Conditions

Cognitive Impairment

Hematologic Neoplasms

Hematopoietic Cell Transplant

Eligibility Criteria

Sex: All

Age: 21+

Healthy Volunteers: Not accepted

Interventions

Lumosity

Lumosity (waitlist control)

Study Details

Brief summary:

A pilot study to evaluate feasibility of enrollment of patients in an intervention to improve neurocognitive function in hematopoietic cell transplantation (HCT) survivors using the cognitive training Lumosity program. In addition, patients' interest in receiving information regarding genetic risk of cognitive impairment post-HCT will be measured.

Conditions

Cognitive Impairment

Hematologic Neoplasms

Hematopoietic Cell Transplant

Study ID

NCT03094026

Start date

Aug 21, 2017

Status verified date

Apr, 2026

Completion date

Jul, 2027

Anticipated

Primary completion date

Jul, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 21+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • ≥ 21 years old at time of allogeneic HCT performed at UAB
  • Outpatient and between 3 and 6 months post HCT
  • English speaking
  • Possess access to an internet-connected home computer

Exclusion criteria:

  • History of pre-existing neurological disorder or documented major psychiatric disorder; significant auditory, visual, or motor impairments
  • Participated in neuropsychological intervention within the past 6 months
  • History of color blindness

Study Design

Enrollment

60 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

experimental: Intervention

The arm will begin the Lumosity program at enrollment in the study.

active comparator: Wait List Control

The arm will begin the Lumosity program 3 months after enrollment in the study.

Interventions

Lumosity

Computer-based online cognitive training program using the Lumosity cognitive training program.

Lumosity (waitlist control)

Computer-based online cognitive training program using the Lumosity cognitive training program. The control group will receive the intervention after a waiting period of 12 weeks.

Primary outcome measure

  • Number of HCT patients completing the 2-arm wait-listed randomized trial of cognitive training intervention for a period of 3 months [ Time Frame: 12 weeks ]
  • Change in cognitive function between intervention and wait list control arms from baseline to 12 weeks. [ Time Frame: Baseline to 12 weeks ]

Central Contacts and Locations

Central contacts

Noha M Sharafeldin, MD,MSc, PhD

2056382144nsharaf@uab.edu

Lindsey Hageman, MPH

2056382139lhageman@peds.uab.edu

Locations

University of Alabama at Birmingham

Recruiting

Birmingham, Alabama, United States, 35233

Contacts

Noha Sharafeldin, MD, MSc, PhD

2056382144nsharaf@uab.edu

Lindsey Hageman, MPH, CCRP

2056382139lhageman@peds.uab.edu

More Information

Sponsor

University of Alabama at Birmingham

Last update posted

Apr 20, 2026

Last verified

Apr, 2026

Keywords

  • Hematologic cancers
  • Hematopoietic cell transplantation
  • cognitive training
  • genetic knowledge
  • genetic attitude
  • adult cancer survivors

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Alabama at Birmingham on 2026-04-20.