Recruiting

Observational Study

Sponsor:

Stony Brook University

Code:

NCT03140592

Conditions

Pancreatic Cancer

Pancreatic Adenocarcinoma

Pancreatic Cyst

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Biopsy

Study Details

Brief summary:

Pancreatic cancer is a very aggressive cancer. Over the past 40 years there has not been much progress made in reducing deaths from this cancer. Recently, new models of pancreatic cancers have been generated from mouse and human tissues. These models have used larger pieces of tissues taken from surgical removal of pancreatic cancers.

The purpose of this study is to determine whether these new pancreatic cancer models can be generated from the small biopsies we take to make the diagnosis of the pancreatic mass.

Conditions

Pancreatic Cancer

Pancreatic Adenocarcinoma

Pancreatic Cyst

Study ID

NCT03140592

Start date

Jan 14, 2015

Status verified date

Mar, 2021

Completion date

Jan, 2023

Anticipated

Primary completion date

Jan, 2023

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

1. Patients who are scheduled for an EUS-FNB of pancreatic mass(es) suspicious for pancreatic ductal adenocarcinoma performed by a member of the Stony Brook Interventional Endoscopy Section of the Division of Gastroenterology and Hepatology

1. Age ≥ 18 years
2. Literate and able/willing to provide informed consent for participation in research.

Exclusion Criteria:

1. Age < 18 years
2. Not literate or unable/unwilling to provide informed consent for EUS-FNB research biopsies
3. Pregnancy as determined by serum or urine HCG test performed as standard of clinical care for all women of childbearing age and documented on subjects' electronic medical record

Study Design

Enrollment

300 participants

Anticipated

Interventions and Outcome Measures

Interventions

Biopsy

Two extra EUS guided pancreatic biopsies collected for only research purposes.

Primary outcome measure

  • Successful generation of pancreatic organoids [ Time Frame: 6 years ]

Central Contacts and Locations

Central contacts

Jonathan Buscaglia, MD

6314447225jonathan.buscaglia@stonybrookmedicine.edu

Joseph LaComb, BS

6314449532joseph.lacomb@stonybrookmedicine.edu

Locations

Stony Brook University

Recruiting

Stony Brook, New York, United States, 11794

Contacts

Jonathan Buscaglia, MD

jonathan.buscaglia@stonybrookmedicine.edu

More Information

Sponsor

Stony Brook University

Last update posted

Mar 19, 2021

Last verified

Mar, 2021

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Stony Brook University on 2021-03-19.