Recruiting

Observational Study

Sponsor:

The University of Texas Health Science Center, Houston

Code:

NCT03185702

Conditions

Turner Syndrome

Eligibility Criteria

Sex: Female

Age: 0+

Healthy Volunteers: Not accepted

Interventions

Research genetic tests

Study Details

Brief summary:

The investigators will conduct genetic comparisons between Turner Syndrome (TS) patients with and without Bicuspid Aortic Valve (BAV) to identify causative agents of BAV in people with TS.

The investigators will correlate the patterns and prevalence of structural heart defects in TS women with emerging molecular data to identify patients who are at high risk for cardiovascular complications

Conditions

Turner Syndrome

Study ID

NCT03185702

Start date

Aug 28, 2015

Status verified date

Nov, 2023

Completion date

Jan 1, 2035

Anticipated

Primary completion date

Jan 1, 2030

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Female

Age: 0+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Diagnosis of Turner Syndrome

Exclusion Criteria:

  • Diagnosis excluding Turner Syndrome

Study Design

Enrollment

200 participants

Anticipated

Interventions and Outcome Measures

Arms

Patients with Turner Syndrome

Chromosomal diagnosis and typical features

Unaffected controls

Normal females and unaffected family members

Interventions

Research genetic tests

DNA and tissue-based tests: karyotype, copy number variants, genome-wide association studies and induced pluripotent stem cells

Primary outcome measure

  • Bicuspid aortic valve and thoracic aortic aneurysm [ Time Frame: 10 years ]

Central Contacts and Locations

Central contacts

Siddharth Prakash, MD, PhD

7135007003Siddharth.K.Prakash@uth.tmc.edu

Locations

University of Texas Health Science Center Houston

Recruiting

Houston, Texas, United States, 77030

Contacts

Jacqueline Jennings

TSRegistry@uth.tmc.edu

713-500-6704

Principal Investigator:

Michelle Rivera-Davila, MD

More Information

Sponsor

The University of Texas Health Science Center, Houston

Last update posted

Nov 28, 2023

Last verified

Nov, 2023

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by The University of Texas Health Science Center, Houston on 2023-11-28.