Recruiting

Observational Study

Sponsor:

University of Nebraska

Code:

NCT03192267

Conditions

Rheumatoid Arthritis

Eligibility Criteria

Sex: All

Age: 19 - 70+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

Extra-articular (outside of joints) disease occurs in approximately 50% of rheumatoid arthritis (RA) patients, with the lung being a common site of involvement. The goals of this study are to investigate and characterize lung disease and its prevalence in early RA participants. This will be done through pulmonary function and high resolution chest computed tomography (CT), questionnaires, and serum studies. Another goal is to find novel biomarkers, such anti-malondialdehyde-acetaldehyde (MAA) antibodies, as predictors of lung disease in RA participants.

Conditions

Rheumatoid Arthritis

Study ID

NCT03192267

Start date

Mar 31, 2017

Status verified date

Jul, 2026

Completion date

Mar, 2030

Anticipated

Primary completion date

Mar, 2029

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 19 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • 19-90 years of age
  • Able to give informed consent
  • Diagnosis of RA by a Rheumatologist using 2010 American College of Rheumatology (ACR) criteria within the past 2 years

Exclusion Criteria:

  • Inflammatory arthritis that does not meet 2010 American College of Rheumatology (ACR) criteria for rheumatoid arthritis (RA)
  • Pregnant

Study Design

Enrollment

125 participants

Anticipated

Interventions and Outcome Measures

Arms

No treatment

No treatment

Primary outcome measure

  • High Resolution Computed Tomography Chest Scan Results [ Time Frame: Baseline (Visit 1 only) ]

Central Contacts and Locations

Central contacts

Aimee B Schreiner, MS

402-559-4873aischreiner@unmc.edu

Bridget Kramer, RN

402-559-7288bridget.kramer@unmc.edu

Locations

University of Nebraska Medical Center

Recruiting

Omaha, Nebraska, United States, 68198

Contacts

Bridget Kramer, RN

402-559-4510bridget.kramer@unmc.edu

Principal Investigator:

Bryant R England, MD

More Information

Sponsor

University of Nebraska

Last update posted

Jul 9, 2026

Last verified

Jul, 2026

Keywords

  • newly diagnosed rheumatoid arthritis
  • lung disease

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Nebraska on 2026-07-09.