Recruiting

Cerebellar Stimulation

Sponsor:

Krystal Parker, PhD

Code:

NCT03217110

Conditions

Schizophrenia

Autism Spectrum Disorder

Bipolar Disorder

Depression

Parkinson Disease

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Accepted

Interventions

Repetitive Transcranial Magnetic Stimulation (rTMS)

Sham Repetitive Transcranial Magnetic Stimulation (rTMS)

Study Details

Brief summary:

The purpose of this study is to examine whether cerebellar stimulation can be used to improve cognitive deficits and mood in patients with schizophrenia, autism, bipolar disorder, Parkinson's disease, and major depression.

Conditions

Schizophrenia

Autism Spectrum Disorder

Bipolar Disorder

Depression

Parkinson Disease

Study ID

NCT03217110

Start date

Nov 30, 2017

Status verified date

Mar, 2026

Completion date

Dec 1, 2028

Anticipated

Primary completion date

Dec 1, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • A clinical diagnosis consistent with enrollment

Exclusion Criteria:

  • History of recurrent seizures or epilepsy
  • Any other neurological or psychiatric diagnosis outside the diagnosis for which the participant is enrolled.
  • Active substance use disorder in the past 6 months other than tobacco use disorder.
  • Inability to consent for study.
  • Pacemaker
  • Coronary Stent
  • Defibrillator
  • Neurostimulation
  • Claustrophobia
  • Uncontrolled high blood pressure
  • Atrial fibrillation
  • Significant heart disease
  • Hemodynamic instability
  • Kidney disease
  • Pregnant, trying to become pregnant, or breast feeding

Study Design

Enrollment

200 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: patient active rTMS

Subjects will receive 5 days of 2x daily rTMS targeted over the cerebellum.

sham comparator: patient sham rTMS

Subjects will receive 5 days of 2x daily sham stimulation of the cerebellum.

active comparator: Control active rTMS

sham comparator: Control sham rTMS

Interventions

Repetitive Transcranial Magnetic Stimulation (rTMS)

Subjects with neuropsychiatric diagnoses and matched-controls will be receive theta frequency stimulation of the cerebellum. We will target the cerebellar vermis.

Sham Repetitive Transcranial Magnetic Stimulation (rTMS)

Subjects with neuropsychiatric diagnoses and matched-controls will be receive sham stimulation of the cerebellum. We will target the cerebellar vermis.

Primary outcome measure

  • Change in disease-specific symptom rating scale, one scale identified for each group (MADRS for bipolar group; PANSS for schizophrenia group; UPDRS in Parkinson's patient group). [ Time Frame: During the 1 week of treatment, with follow up 1 week, 3 weeks, and 2 months post-stimulation. ]

Central Contacts and Locations

Central contacts

Krystal L Parker, Ph.D

319-353-4554CT201610712@gmail.com

Benjamin Pace, M.S.

319-384-9302benjamin-pace@uiowa.edu

Locations

University of Iowa

Recruiting

Iowa City, Iowa, United States, 52245

Contacts

Krystal L Parker, Ph.D

319-353-3554krystal-parker@uiowa.edu

More Information

Sponsor

Krystal Parker, PhD

Last update posted

Mar 19, 2026

Last verified

Mar, 2026

Keywords

  • Cerebellum

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by Krystal Parker, PhD on 2026-03-19.