Recruiting

Functional Assessment

Sponsor:

UCLA

Code:

NCT03228290

Conditions

End Stage Liver Disease

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

This will be a prospective cohort study of patients with liver disease. Subjects will undergo geriatric assessments of frailty, functional status, and disability using functional status measures at baseline and at every clinic visit in the pre-transplant setting. Subjects will also answer questions regarding quality of life, personality, and/or cognitive function. Subjects will again undergo assessments at every clinic visit through 12 months after transplant. Then, they will be followed annually.

Conditions

End Stage Liver Disease

Study ID

NCT03228290

Start date

Oct 12, 2011

Status verified date

Jul, 2026

Completion date

Dec 31, 2030

Anticipated

Primary completion date

Dec 31, 2030

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Adult (≥18 years old)
  • Are seen for the treatment of liver disease

Study Design

Enrollment

5000 participants

Anticipated

Interventions and Outcome Measures

Primary outcome measure

  • Frailty and functional status as assessed by grip strength, chair stands, and balance which comprise the Liver Frailty Index (LFI). [ Time Frame: December 31, 2023 ]
  • Examine the association between frailty and outcomes both before and after liver transplantation. [ Time Frame: December 31, 2023 ]
  • Evaluate the change in frailty and physical function both before and after liver transplant or treatment utilizing the LFI. [ Time Frame: December 31, 2023 ]

Central Contacts and Locations

Central contacts

Jennifer C Lai, MD, MBA

(415) 476-6422jennifer.lai@ucsf.edu

Fawzy Barry, BS

(415) 476-6119fawzy.barry@ucsf.edu

Locations

University of California, San Francisco

Recruiting

San Francisco, California, United States, 94143

Contacts

Jennifer C Lai, MD, MBA

415-476-2777jennifer.lai@ucsf.edu

Fawzy Barry, BS

415-476-6119fawzy.barry@ucsf.edu

Principal Investigator:

Jennifer C Lai, MD, MBA

Northwestern University

Recruiting

Chicago, Illinois, United States, 60611

Contacts

Daniel Ganger, MD

312-695-4496dganger@nmff.org

Harika Reddy, BS

harika.reddy@northwestern.edu

Johns Hopkins

Recruiting

Baltimore, Maryland, United States, 21287

Contacts

Betsy King, MD

630-244-6464eking19@jhmi.edu

Sherry Leung, BS

sleung7@jhu.edu

Columbia University

Recruiting

New York, New York, United States, 10032

Contacts

Elizabeth Verna, MD

212-305-9139ev77@columbia.edu

Geena George

212-305-3839gg2827@cumc.columbia.edu

Duke University Medical Center

Recruiting

Durham, North Carolina, United States, 27710

Contacts

Matthew Kappus, MD

804-828-8786matthew.kappus@duke.edu

Adele Gaskin

919-684-0742adele.gaskin@duke.edu

University of Pittsburgh

Recruiting

Pittsburgh, Pennsylvania, United States, 15237

Contacts

Amit Tevar, MD

tevara@upmc.edu

Rita Johnson, RN

412-383-8616johnsonr1@upmc.edu

Baylor Scott & White Health

Recruiting

Dallas, Texas, United States, 75246

Contacts

Robert Rahimi, MD

214-820-8500Robert.Rahimi@BSWHealth.org

Abby Mertz, BS

214-818-7873Abby.Mertz@BSWHealth.org

University of Washington

Recruiting

Seattle, Washington, United States, 98195

Contacts

Meredith Pearson, MD

mmp9h@medicine.washington.edu

James Kashima, BS

(206) 685-3135kashij@uw.edu

More Information

Sponsor

University of California, San Francisco

Last update posted

Jul 14, 2026

Last verified

Jul, 2026

Keywords

  • Cirrhosis
  • Liver
  • Liver Transplant
  • Frailty
  • end stage

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by University of California, San Francisco on 2026-07-14.