Recruiting

Observational Study

Sponsor:

Stanford University

Code:

NCT03231241

Conditions

Chronic Daily Headache

Chronic Migraine

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Study Details

Brief summary:

Study is aimed at determining why some patients with episodic headache proceed to chronic daily or near daily headaches. The Investigators seek to discover differences in brain anatomy and function, composition of cerebrospinal fluid, blood products, genetics, and patient phenotypes that might help explain this process.

Conditions

Chronic Daily Headache

Chronic Migraine

Study ID

NCT03231241

Start date

Dec 12, 2014

Status verified date

Dec, 2024

Completion date

Sep 1, 2026

Anticipated

Primary completion date

Aug 15, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Subjects must agree to sign informed consent.
  • Subject must be able to or at least with some help willing to complete online questionnaires in English .
  • Willing to comply with study instructions.
  • must speak and understand English

Exclusion Criteria:

\*Any neurological condition, at the discretion of the Principal Investigator (PI)

Study Design

Enrollment

700 participants

Anticipated

Interventions and Outcome Measures

Arms

Episodic Headache

Participants experiencing headache of any type more than twice per year but less than 15 days per month. No interventions

Chronic Headache

Participants experiencing headache more than 15 days per month for at least three consecutive months. No interventions

Control

Participants reporting fewer than two headaches per year. No interventions

Primary outcome measure

  • Prediction of chronification of headache [ Time Frame: five years ]

Central Contacts and Locations

Central contacts

Bharati Sanjanwala, M.Sc.

650-721-2830bharatis@stanford.edu

Anthony Bet, B.S.

650-683-5823abet0915@stanford.edu

Locations

Stanford University School of Medicine

Recruiting

Stanford, California, United States, 94304

Contacts

Bharati Sanjanwala, M.Sc.

650-721-2830bharatis@stanford.edu

Anthony Bet, B.S.

650-683-5823abet0915@stanford.edu

More Information

Sponsor

Stanford University

Last update posted

Jul 23, 2025

Last verified

Dec, 2024

Keywords

  • Headaches
  • Tension-Type Headache
  • New Daily Persistent Headache (NDPH)
  • Migraine

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Stanford University on 2025-07-23.