Recruiting
Phase 2

Chemotherapy with Metformin

Sponsor:

Qamar Khan

Code:

NCT03238495

Conditions

HER2-positive Breast Cancer

Eligibility Criteria

Sex: Female

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Taxotere, Carboplatin, Herceptin + Pertuzumab

Metformin

Study Details

Brief summary:

The primary objective of this study is to determine the efficacy of metformin as a repurposed agent in human epidermal growth factor receptor 2 (HER2) positive breast cancer when added to standard neo-adjuvant chemotherapy.

Conditions

HER2-positive Breast Cancer

Study ID

NCT03238495

Start date

Aug 15, 2017

Status verified date

Dec, 2021

Completion date

Jun 1, 2023

Anticipated

Primary completion date

Jun 1, 2022

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Female

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Eastern Cooperative Oncology Group Performance Status (ECOG PS) 0-1.
  • Unilateral or bilateral primary carcinoma of the breast, confirmed histologically by needle core biopsy. Fine-needle aspiration is not sufficient. Incisional/excisional biopsy is not allowed. In case of bilateral cancer, the investigator has to decide prospectively which side will be evaluated for the primary endpoint.
  • Study participants must be cT1c - cT4a-d, any node (N), no metastases (M0). Any tumor (T) is allowed if node positive (biopsy proven and HER2 positive) including no primary invasive cancer or only ductal carcinoma in situ (DCIS). Metastatic workup is not required.
  • Breast tumor must be >1.5 cm in maximum diameter by clinical or any radiologic measurement, if node negative. If node is positive by biopsy, study participant will be eligible regardless of the size of the breast primary. In case of inflammatory breast cancer, the extent of inflammation/erythema can be used as measurable lesion.
  • Multifocal or multicentric breast cancer is allowed if all the lesions are biopsied and are HER2 positive. Largest lesion will be assigned the target lesion.
  • Must be HER2-positive in primary breast tumor or lymph node by the ASCO/CAP guidelines 2013: http://www.asco.org/guidelines/her2
  • Ejection fraction (EF) greater than 50% by MUGA or ECHO within 4 weeks prior to first dose of study treatment.
  • No prior cancer chemotherapy allowed.
  • Adequate organ and marrow function as defined below, unless deemed non-clinically significant and approved by the Principal Investigator:

  • Absolute neutrophil count ≥ 1,500/mcL
  • Platelets ≥ 100,000/mcl
  • total bilirubin within normal institutional limits
  • AST(SGOT) ≤ 2.5 X institutional upper limit of normal
  • ALT(SPGT) ≤ 2.5 X institutional upper limit of normal
  • ALK Phos ≤ 2.5 X institutional upper limit of normal
  • Creatinine clearance > 50mL/min
  • Women of child-bearing potential must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry, for the duration of study participation, and for 90 days following completion of therapy.
  • Negative pregnancy test within 14 days prior to randomization

Exclusion Criteria:

  • Pregnant, breastfeeding, or unwilling to practice birth control during participation in the study
  • Presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the study participant or the quality of the study data.
  • Current or anticipated use of other investigational agents.
  • Prior chemotherapy for any malignancy.
  • Prior radiation therapy for breast cancer
  • Previous malignant disease being disease-free for less than 5 years (except carcinoma in situ (CIS) of the cervix and non-melanoma skin cancer).
  • Patients with diabetes on metformin. Patients with diabetes and not on metformin will be eligible if it is deemed safe after consultation with the patient physician managing diabetes.
  • History of allergic reactions attributed to compounds of similar chemical or biologic composition to metformin or other agents used in study.
  • Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.

Study Design

Enrollment

100 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

active comparator: Chemotherapy Only

Taxotere, Carboplatin, Herceptin + Pertuzumab (TCH+P)

experimental: Chemotherapy plus Metformin

TCH+P plus metformin

Interventions

Taxotere, Carboplatin, Herceptin + Pertuzumab

TCH+P chemotherapy every 3 weeks for 6 cycles: Taxotere 75mg/m2, Carboplatin AUC 6, Herceptin 6mg/kg (first cycle loading dose of 8mg/kg), Pertuzumab 420mg (first cycle loading does of 840mg)

Metformin

TCH+P chemotherapy every 3 weeks for 6 cycles. Metformin 850 mg daily during the first cycle, then 850 mg twice daily for the remaining 5 cycles.

Primary outcome measure

  • Pathologic complete response (pCR) [ Time Frame: Up to 6 weeks after last chemotherapy treatment ]

Central Contacts and Locations

Central contacts

Clinical Trials Nurse Navigator

913-945-7552ctnursenav@kumc.edu

Locations

The University of Kansas Cancer Center, West Clinic

Recruiting

Kansas City, Kansas, United States, 66112

Contacts

Clinical Trials Nurse Navigator

913-945-7552ctnursenav@kumc.edu

The University of Kansas Cancer Center, Westwood Campus

Recruiting

Kansas City, Kansas, United States, 66205

Contacts

Clinical Trials Nurse Navigator

913-945-7552ctnursenav@kumc.edu

The University of Kansas Cancer Center, Overland Park Clinic

Recruiting

Overland Park, Kansas, United States, 66210

Contacts

Clinical Trials Nurse Navigator

913-945-7552ctnursenav@kumc.edu

The University of Kansas Cancer Center, South Clinic

Recruiting

Kansas City, Missouri, United States, 64131

Contacts

Clinical Trials Nurse Navigator

913-945-7552ctnursenav@kumc.edu

The University of Kansas Cancer Center, North Clinic

Recruiting

Kansas City, Missouri, United States, 64154

Contacts

Clinical Trials Nurse Navigator

913-945-7552ctnursenav@kumc.edu

The University of Kansas Cancer Center, Lee's Summit Clinic

Recruiting

Lee's Summit, Missouri, United States, 64064

Contacts

Clinical Trials Nurse Navigator

913-945-7552ctnursenav@kumc.edu

More Information

Sponsor

Qamar Khan

Last update posted

Dec 7, 2021

Last verified

Dec, 2021

Keywords

  • Operable breast cancer
  • Neo-adjuvant chemotherapy

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Qamar Khan on 2021-12-07.