Recruiting

Intrepid™ TMVR

Sponsor:

Medtronic Cardiovascular

Code:

NCT03242642

Conditions

Mitral Valve Regurgitation

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR)

Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR)

Study Details

Brief summary:

Multi-center, global, prospective, non-randomized, interventional, pre-market trial. All subjects enrolled with receive the study device.

Conditions

Mitral Valve Regurgitation

Study ID

NCT03242642

Start date

Oct 23, 2017

Status verified date

Aug, 2026

Completion date

Sep 30, 2036

Anticipated

Primary completion date

May 30, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Moderate to severe or severe symptomatic mitral regurgitation
  • Local site multidisciplinary heart team experienced in mitral valve therapies agrees that the subject is unsuitable for treatment with approved transcatheter repair or conventional mitral valve intervention

Exclusion Criteria:

  • prior transcatheter mitral valve procedure with device currently implanted
  • anatomic contraindications
  • prohibitive mitral annular calcification
  • left ventricular ejection fraction <25%
  • need for emergent or urgent surgery
  • hemodynamic instability

Study Design

Enrollment

1056 participants

Anticipated

Allocation

Non randomized

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Primary Cohort- TMVR

Treatment of mitral regurgitation with the Medtronic Transcatheter Mitral Valve Replacement System (TMVR)

experimental: Mitral Annular Calcification -TMVR

Treatment of mitral regurgitation with the Medtronic Transcatheter Mitral Valve Replacement System (TMVR)

Interventions

Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR)

mitral valve replacement

Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR)

Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR) mitral valve replacement

Primary outcome measure

  • Primary Cohort [ Time Frame: 1 year ]
  • MAC Cohort [ Time Frame: 1 year ]

Central Contacts and Locations

Central contacts

Locations

University of Alabama Birmingham (UAB) Hospital

Recruiting

Birmingham, Alabama, United States, 35233

Contacts

Principal Investigator:

Mustafa Ahmed, MD

Abrazo Heart Hospital

Recruiting

Phoenix, Arizona, United States, 85018

Contacts

Principal Investigator:

Timothy Byrne, MD

Scripps Memorial Hospital

Recruiting

La Jolla, California, United States, 92037

Contacts

Principal Investigator:

Scott Brewster, MD

PIH Health Good Samaritan Hospital

Recruiting

Los Angeles, California, United States, 90017

Contacts

Principal Investigator:

Steven Burstein

Kaiser Permanente Los Angeles Medical Center

Recruiting

Los Angeles, California, United States, 90027

Contacts

Principal Investigator:

Somjot Brar, MD

Keck Hospital of the University of Southern California, USC

Recruiting

Los Angeles, California, United States, 90033

Contacts

Principal Investigator:

Vaughn Starnes, MD

Cedars Sinai Medical Center

Recruiting

Los Angeles, California, United States, 90048

Contacts

Principal Investigator:

Raj Makkar, MD

El Camino Hospital

Recruiting

Mountain View, California, United States, 94040

Contacts

Principal Investigator:

Chad Rammohan, MD

Kaiser Permanente San Francisco Medical Center

Recruiting

San Francisco, California, United States, 94118-3100

Contacts

Principal Investigator:

Ahmad Sheikh, MD

Stanford Hospital and Clinics

Recruiting

Stanford, California, United States, 94305

Contacts

Principal Investigator:

David Lee, MD

Los Robles Regional Medical Center

Recruiting

Thousand Oaks, California, United States, 91360-1847

Contacts

Principal Investigator:

Saibal Kar, MD

Hartford Hospital

Recruiting

Hartford, Connecticut, United States, 06102

Contacts

Principal Investigator:

Talhat Azemi, MD

Yale New Haven Hospital

Recruiting

New Haven, Connecticut, United States, 06510

Contacts

Principal Investigator:

John Forrest, MD

MedStar Washington Hospital Center

Recruiting

Washington D.C., District of Columbia, United States, 20010

Contacts

Principal Investigator:

Ron Waksman, MD

JFK Medical Center

Recruiting

Atlantis, Florida, United States, 33462

Contacts

Principal Investigator:

Mark Rothenberg, MD

Morton Plant

Recruiting

Clearwater, Florida, United States, 33756

Contacts

Principal Investigator:

Lang L Lin, MD

HealthPark Medical Center

Recruiting

Fort Myers, Florida, United States, 33908

Contacts

Principal Investigator:

Murali Muppala, MD

North Florida Regional Medical Center

Recruiting

Gainesville, Florida, United States, 32605

Contacts

Principal Investigator:

Ilie Barb, MD

Baptist Medical Center Jacksonville

Recruiting

Jacksonville, Florida, United States, 32207

Contacts

Principal Investigator:

Ruby Satpahy, MD

University of South Florida Health

Recruiting

Tampa, Florida, United States, 33606

Contacts

Principal Investigator:

Hiram Bezerra, MD

Emory University

Recruiting

Atlanta, Georgia, United States, 30308

Contacts

Principal Investigator:

Adam Greenbaum, MD

Piedmont Atlanta Hospital

Recruiting

Atlanta, Georgia, United States, 30309

Contacts

Principal Investigator:

Pradeep Yadav, MD

Northwestern Memorial Hospital

Recruiting

Chicago, Illinois, United States, 60611

Contacts

Principal Investigator:

S. Chris Malaisrie, MD

Rush University Medical Center

Recruiting

Chicago, Illinois, United States, 60612

Contacts

Principal Investigator:

Hussam Suradi, MD

MercyOne Des Moines Medical Center

Recruiting

Des Moines, Iowa, United States, 50314

Contacts

Principal Investigator:

Atul Chawla, MD

University of Kansas Medical Center

Recruiting

Kansas City, Kansas, United States, 66160

Contacts

Principal Investigator:

Mark Wiley, MD

The Johns Hopkins Hospital

Recruiting

Baltimore, Maryland, United States, 21287

Contacts

Principal Investigator:

Rani Hasan, MD

Massachusetts General Hospital

Recruiting

Boston, Massachusetts, United States, 02114

Contacts

Principal Investigator:

Ignacio Inglessis, MD

Brigham and Women's Hospital

Recruiting

Boston, Massachusetts, United States, 02115

Contacts

Principal Investigator:

Pinak Bipin Shah, MD

Beth Israel Deaconess Medical Center

Recruiting

Boston, Massachusetts, United States, 02215

Contacts

Principal Investigator:

Roger Laham, MD

University of Michigan Health System

Recruiting

Ann Arbor, Michigan, United States, 48109

Contacts

Principal Investigator:

Stanley Chetcuti, MD

Henry Ford Saint John Hospital

Recruiting

Detroit, Michigan, United States, 48236

Contacts

Principal Investigator:

Theodore Schreiber, MD

Corewell Health

Recruiting

Grand Rapids, Michigan, United States, 49503

Contacts

Principal Investigator:

William Merhi, MD

Abbott Northwestern Hospital

Recruiting

Minneapolis, Minnesota, United States, 55407

Contacts

Principal Investigator:

Vinayak Bapat, MD

Barnes-Jewish Hospital

Recruiting

St Louis, Missouri, United States, 63110-1003

Contacts

Principal Investigator:

Alan Zajarias, MD

Morristown Medical Center

Recruiting

Morristown, New Jersey, United States, 07960

Contacts

Principal Investigator:

Philippe Genereux, MD

Jersey Shore University Medical Center

Recruiting

Neptune City, New Jersey, United States, 07753

Contacts

Principal Investigator:

Matthew Saybolt

Northwell Health North Shore University Hospital

Recruiting

Manhasset, New York, United States, 11030

Contacts

Principal Investigator:

Bruce Rutkin, MD

NYU Langone Medical Center

Recruiting

New York, New York, United States, 10016

Contacts

Principal Investigator:

Matthew Williams, MD

The Mount Sinai Hospital

Recruiting

New York, New York, United States, 10029

Contacts

Principal Investigator:

Samin Sharma, MD

Montefiore Medical Center

Recruiting

New York, New York, United States, 10467-2401

Contacts

Principal Investigator:

Azeem Latib, MD

Saint Francis Hospital

Recruiting

Roslyn, New York, United States, 11576

Contacts

Principal Investigator:

George Petrossian, MD

The Christ Hospital

Recruiting

Cincinnati, Ohio, United States, 45219-2906

Contacts

Principal Investigator:

Puvi Seshiah, MD

University Hospitals Cleveland Medical Center

Recruiting

Cleveland, Ohio, United States, 44106

Contacts

Principal Investigator:

Guilherme Attizzani, MD

The Ohio State University Wexner Medical Center

Recruiting

Columbus, Ohio, United States, 43210

Contacts

Principal Investigator:

Konstantinos Boudoulas, MD

OhioHealth Riverside Methodist Hospital

Recruiting

Columbus, Ohio, United States, 43214

Contacts

Principal Investigator:

Steven Yakubov, MD

Integris Baptist Medical Center

Recruiting

Oklahoma City, Oklahoma, United States, 73112

Contacts

Principal Investigator:

Jeffrey Sparling, MD

Providence Saint Vincent Medical Center

Recruiting

Portland, Oregon, United States, 97225

Contacts

Principal Investigator:

Brandon Jones, MD

Oregon Health & Science University Hospital

Recruiting

Portland, Oregon, United States, 97239

Contacts

Principal Investigator:

Firas Zahr, MD

UPMC Pinnacle Harrisburg Campus

Recruiting

Harrisburg, Pennsylvania, United States, 17101

Contacts

Principal Investigator:

Arun Kanmanthareddy, MD

UPMC Presbyterian

Recruiting

Pittsburgh, Pennsylvania, United States, 15213

Contacts

Principal Investigator:

Conrad Smith, MD

Lankenau Medical Center

Recruiting

Wynnewood, Pennsylvania, United States, 19096

Contacts

Principal Investigator:

Scott S Goldman, MD

Vanderbilt University Medical Center

Recruiting

Nashville, Tennessee, United States, 37203

Contacts

Principal Investigator:

Tarek Absi, MD

Heart Hospital of Austin

Recruiting

Austin, Texas, United States, 78756

Contacts

Principal Investigator:

John Moscona, MD

Texas Health Presbyterian Hospital Dallas

Recruiting

Dallas, Texas, United States, 75231

Contacts

Principal Investigator:

James Park, MD

CHI Saint Luke's Health-Baylor Saint Luke's Medical Center

Recruiting

Houston, Texas, United States, 77030

Contacts

Principal Investigator:

Guilherme Silva, MD

Houston Methodist Hospital

Recruiting

Houston, Texas, United States, 77030

Contacts

Principal Investigator:

Neal Kleiman, MD

The University of Texas Health Science Center at Houston

Recruiting

Houston, Texas, United States, 77030

Contacts

Principal Investigator:

Richard Smalling, MD

The Heart Hospital Baylor Plano

Recruiting

Plano, Texas, United States, 75093

Contacts

Principal Investigator:

Molly Szerlip, MD

Methodist Hospital

Recruiting

San Antonio, Texas, United States, 78229

Contacts

Principal Investigator:

Jorge Alvarez, MD

The University of Vermont Medical Center

Recruiting

Burlington, Vermont, United States, 05401-1473

Contacts

Principal Investigator:

Harold Dauerman, MD

University of Virginia Medical Center

Recruiting

Charlottesville, Virginia, United States, 22908

Contacts

Principal Investigator:

John Saxon, MD

Inova Fairfax Hospital

Recruiting

Fairfax, Virginia, United States, 22042

Contacts

Principal Investigator:

Shahram Yazdani, MD

Sentara Norfolk General Hospital

Recruiting

Norfolk, Virginia, United States, 23507-1904

Contacts

Principal Investigator:

Matthew Summers, MD

University of Washington (UW) Medical Center

Recruiting

Seattle, Washington, United States, 98195

Contacts

Principal Investigator:

Christine Chung, MD

Providence Sacred Heart Medical Center & Children's Hospital

Recruiting

Spokane, Washington, United States, 99204

Contacts

Principal Investigator:

Jonathan Hansen, MD

Aurora St. Luke's Medical Center

Recruiting

Milwaukee, Wisconsin, United States, 53215

Contacts

Principal Investigator:

Tanvir Bajwa, MD

Royal Columbian Hospital

Recruiting

New Westminster, British Columbia, Canada, V3L 3W7

Contacts

Principal Investigator:

Razi Khan, MD

Saint Paul's Hospital

Recruiting

Vancouver, British Columbia, Canada, V6Z 1Y6

Contacts

Principal Investigator:

David Wood, MD

Sunnybrook Health Sciences Centre

Recruiting

Toronto, Ontario, Canada, M4N 3M5

Contacts

Principal Investigator:

Andrew Czarnecki, MD

Saint Michael's Hospital

Recruiting

Toronto, Ontario, Canada, M5B 1W8

Contacts

Principal Investigator:

Neil Fam, MD

Montreal Heart Insitute

Recruiting

Montreal, Quebec, Canada, H1T 1C8

Contacts

Principal Investigator:

Ralph Stephan von Bardeleben, MD

Glen Royal Victoria Hospital

Recruiting

Montreal, Quebec, Canada, H4A 3J1

Contacts

Principal Investigator:

Nicolo Piazza

More Information

Sponsor

Medtronic Cardiovascular

Last update posted

Aug 5, 2026

Last verified

Aug, 2026

Keywords

  • Heart disease
  • valve disease
  • heart valve disease
  • mitral regurgitation
  • cardiovascular disease
  • mitral insufficiency

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by Medtronic Cardiovascular on 2026-08-05.