Recruiting

Observational Study

Sponsor:

University of British Columbia

Code:

NCT03245801

Conditions

Juvenile Idiopathic Arthritis (JIA)

Eligibility Criteria

Sex: All

Age: 0 - 18

Healthy Volunteers: Not accepted

Study Details

Brief summary:

Juvenile Idiopathic Arthritis (JIA) is a disorder of unknown cause characterized by chronic inflammation of the joints and other organs. It affects about 1 in a 1000 Canadian children and if untreated it can produce lifelong disability. The Canadian Alliance of Pediatric Rheumatology Investigators (CAPRI) includes most pediatric rheumatologists in Canada. They have successfully collaborated for the past 20 years producing groundbreaking research on the modern course and outcomes of JIA. The CAPRI JIA Registry is an ongoing universal registry of Canadian children with JIA that collects longitudinal data on disease course, outcomes and adverse events to inform healthcare decisions and to gain new insights into the disease and its treatment.

Conditions

Juvenile Idiopathic Arthritis (JIA)

Study ID

NCT03245801

Start date

Feb 1, 2017

Status verified date

Jun, 2025

Completion date

Feb 1, 2026

Anticipated

Primary completion date

Feb 1, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0 - 18

Healthy Volunteers: Not accepted

Inclusion Criteria:

1. All patients newly diagnosed with JIA within the last 3 months
2. All patients who participated in the original ReACCh-Out study
3. LEAP study patients from 'newly diagnosed' and 'ReACCh-Out' cohorts who have completed their two year follow up in LEAP

Exclusion Criteria:

1. Patients with an unconfirmed JIA diagnosis
2. Patients diagnosed with JIA more than 3 months prior to the clinic visit, who were not followed in LEAP and /or ReACCh-Out studies.
3. If the family as a whole is unable to answer questionnaires in English or French

Study Design

Enrollment

1238 participants

Anticipated

Interventions and Outcome Measures

Primary outcome measure

  • Proportion of Children with Clinical inactive disease [ Time Frame: At one year ]

Central Contacts and Locations

Central contacts

Jaime Guzman, MD, FRCPC

604-875-2437jguzman@cw.bc.ca

Martha Sieres

6048752000martha.sieres@cw.bc.ca

Locations

University of Calgary / Alberta Children's Hospital

Recruiting

Calgary, Alberta, Canada

University of Alberta

Recruiting

Edmonton, Alberta, Canada

BC Children's Hospital

Recruiting

Vancouver, British Columbia, Canada, V6H 3N1

Principal Investigator:

Jaime Guzman, MD, FRCPC

University of Manitoba/Children's hospital research institute

Recruiting

Winnipeg, Manitoba, Canada

Memorial University/Janeway Childrens Health and Rehabilitation Centre

Recruiting

St. John's, Newfoundland and Labrador, Canada, Canada

IIWK Health Centre

Recruiting

Halifax, Nova Scotia, Canada

McMaster University/McMaster Children's Hospital

Recruiting

Hamilton, Ontario, Canada

London Health Sciences Centre

Recruiting

London, Ontario, Canada

Children's Hospital of Eastern Ontario

Recruiting

Ottawa, Ontario, Canada

Principal Investigator:

Ciaran Duffy, MD

Hospital for Sick Children

Recruiting

Toronto, Ontario, Canada

McGill University Health Centre

Recruiting

Montreal, Quebec, Canada

Université de Montréal

Recruiting

Montreal, Quebec, Canada

University of Sherbrooke

Recruiting

Sherbrooke, Quebec, Canada

Royal University Hospital

Recruiting

Saskatoon, Saskatchewan, Canada

CHU Québec - Universite Laval

Recruiting

Québec, Canada

More Information

Sponsor

University of British Columbia

Last update posted

Jun 25, 2025

Last verified

Jun, 2025

Keywords

  • Juvenile idiopathic arthritis
  • Canada
  • Registry
  • Clinical outcomes
  • Adverse events
  • CAPRI

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of British Columbia on 2025-06-25.