Recruiting

Observational Study

Sponsor:

Gelb, Arthur F., M.D.

Code:

NCT03263130

Conditions

COPD, Emphysema, Asthma COPD Overlap

Emphysema

Eligibility Criteria

Sex: All

Age: 30+

Healthy Volunteers: Accepted

Interventions

As above: diagnosis: COPD, Emphysema, Asthma-COPD Overlap

Study Details

Brief summary:

The purpose of this cross-sectional, observational study is to evaluate the site and mechanism(s) for expiratory airflow limitation in chronic, treated, current or former smokers (>15 pack years) with COPD, Emphysema, and Asthma-COPD Overlap with mild to severe expiratory airflow limitation. Treatment may include short and long acting inhaled beta2agonists, short and long acting inhaled muscarinic receptor antagonists, inhaled and or oral corticosteroid, oral antibiotic, supplemental oxygen, and PDE type 4 inhibitor. In some cases, the patient may have had a history of asthma preceding the development of COPD (Asthma COPD Overlap).

Conditions

COPD, Emphysema, Asthma COPD Overlap

Emphysema

Study ID

NCT03263130

Start date

Jan 1, 2017

Status verified date

Oct, 2023

Completion date

Dec 1, 2027

Anticipated

Primary completion date

Jan 1, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 30+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • asthma- copd overlap
  • emphysema in smokers with smoking history > 15 pack years
  • COPD/ bronchitis and bronchiectasis in smokers with smoking history
  • >15 pack years

Exclusion Criteria:other pulmonary or systemic diagnosis

  • non smokers
  • any other pulmonary diagnosis
  • pulmonary fibrosis

Study Design

Enrollment

60 participants

Anticipated

Interventions and Outcome Measures

Arms

COPD, Emphysema, Asthma-COPD Overlap

Based on clinical, pathologic, laboratory, physiologic and radiologic differences, patient groups can be described.

Interventions

As above: diagnosis: COPD, Emphysema, Asthma-COPD Overlap

Primary outcome measure

  • Site and Mechanism(s) of Expiratory Airflow Limitation [ Time Frame: 4 years ]

Central Contacts and Locations

Central contacts

Arthur F Gelb, MD

562-633-2204afgelb@msn.com

Christine Fraser

562-633-2204familyfrase@msn.com

Locations

Arthur F Gelb MD

Recruiting

Lakewood, California, United States, 90712

Contacts

Arthur F Gelb, MD

562-633-2204afgelb@msn.com

Christine Fraser

562-633-2204familyfrase@msn.com

Principal Investigator:

Arthur F Gelb, MD

Arthur F Gelb MD

Recruiting

Lakewood, California, United States, 90712

Contacts

Arthur F Gelb, MD

562-633-2204afgelb@msn.com

Christine Fraser

562-633-2204familyfrase@msn.com

More Information

Sponsor

Gelb, Arthur F., M.D.

Last update posted

Oct 27, 2023

Last verified

Oct, 2023

Keywords

  • COPD, Emphysema, Asthma COPD Overlap

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Gelb, Arthur F., M.D. on 2023-10-27.