Recruiting

Observational Study

Sponsor:

Centre hospitalier de l'Université de Montréal (CHUM)

Code:

NCT03405779

Conditions

Mechanical Ventilation Complication

Ventilator-Induced Lung Injury

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Lung ultrasonography

Study Details

Brief summary:

The primary objective of the study is to create a small dataset of regional pulmonary strain values in patients suffering from pulmonary diseases under mechanical ventilation in an intensive care setting.

Hypothesis: The analysis of lung ultrasonographic sequences using speckle-tracking allows the determination of local pleural strain in 4 predetermined pulmonary areas in mechanically ventilated patients suffering from pulmonary diseases.

Conditions

Mechanical Ventilation Complication

Ventilator-Induced Lung Injury

Study ID

NCT03405779

Start date

Mar 12, 2018

Status verified date

Sep, 2025

Completion date

Feb 1, 2026

Anticipated

Primary completion date

Jan 1, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Adult intensive care patients under mechanical ventilation suffering from a pulmonary disease with a static lung compliance of less than 40 mL/cm H2O.

Exclusion Criteria:

  • Obesity (Body Mass Index superior to 30 kg/m2)
  • Previous thoracic procedure (chest tube, thoracotomy, thoracoscopy)
  • Intra-abdominal pressure inferior to 15 mm Hg (if available)
  • Previous participation to the study

Study Design

Enrollment

10 participants

Anticipated

Interventions and Outcome Measures

Interventions

Lung ultrasonography

Mechanically ventilated patients suffering from pulmonary diseases will undergo a lung ultrasonography during their stay in the intensive care unit (ICU)

Primary outcome measure

  • Average absolute lateral deformation [ Time Frame: At the end of study on Day 1 ]

Central Contacts and Locations

Central contacts

Martin Girard, MD,FRCPC

514-890-8000martin.girard@umontreal.ca

Julie Desroches, PhD

514-890-8000julie.desroches.chum@ssss.gouv.qc.ca

Locations

Centre Hospitalier de l'Université de Montréal (CHUM)

Recruiting

Montreal, Quebec, Canada, H2X 3E4

Contacts

Martin Girard, MD,FRCPC

514-890-8000martin.girard@umontreal.ca

Julie Desroches, PhD

514-890-8000julie.desroches.chum@ssss.gouv.qc.ca

More Information

Sponsor

Centre hospitalier de l'Université de Montréal (CHUM)

Last update posted

Sep 18, 2025

Last verified

Sep, 2025

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Centre hospitalier de l'Université de Montréal (CHUM) on 2025-09-18.