Recruiting

Observational Study

Sponsor:

Children's Hospital of Philadelphia

Code:

NCT03419260

Conditions

Seizures

Eligibility Criteria

Sex: All

Age: 0 - 18

Healthy Volunteers: Not accepted

Interventions

Clinically indicated EEG monitoring.

Study Details

Brief summary:

Electrographic seizures are common in critically ill patients leading to increased use of resource-intense continuous EEG monitoring for seizure identification and management. When identified, electrographic seizures are generally treated with anti-seizure medications, but there are very limited data available regarding optimal treatment in terms of the efficacy or safety of specific anti-seizure medications or overall management strategies.

This is a single-center prospective observational study. The investigators aim to: (1) track critically ill patients undergoing clinically indicated EEG monitoring and seizure management to identify risk factors for electrographic seizures, (2) create prediction models guiding EEG monitoring resources to the patients at highest risk for seizures, and (3) evaluate our current management strategy in terms of safety.

Conditions

Seizures

Study ID

NCT03419260

Start date

Mar 13, 2017

Status verified date

Jun, 2026

Completion date

Jan 1, 2028

Anticipated

Primary completion date

Jan 1, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0 - 18

Healthy Volunteers: Not accepted

Inclusion Criteria:

1. Care in the Children's Hospital of Philadelphia Pediatric ICU.
2. Clinically indicated continuous EEG monitoring.
3. Age > 1 month to 18 years.

Exclusion Criteria:

1. Admitted for Phase 2 (intracranial) EEG monitoring.
2. Intensivist expects to discontinue technological support in the next two days given underlying medical or neurological problems.

Study Design

Enrollment

2500 participants

Anticipated

Interventions and Outcome Measures

Arms

Cohort

Critically ill child undergoing clinically indicated EEG monitoring and electrographic seizure management.

Interventions

Clinically indicated EEG monitoring.

Children enrolled in the study will be undergoing clinically indicated EEG monitoring. Some children will undergo clinically indicated electrographic seizure management.

Primary outcome measure

  • Electrographic Seizure Occurrence [ Time Frame: 3 days ]

Central Contacts and Locations

Central contacts

Nicholas S Abend, MD

215-590-1719abend@chop.edu

Locations

Children's Hospital of Philadelphia

Recruiting

Philadelphia, Pennsylvania, United States, 19104

Contacts

Nichoals S Abend, MD

215-590-1719

More Information

Sponsor

Children's Hospital of Philadelphia

Last update posted

Jun 29, 2026

Last verified

Jun, 2026

Keywords

  • seizures
  • status epilepticus
  • EEG monitoring

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by Children's Hospital of Philadelphia on 2026-06-29.