Recruiting

Observational Study

Sponsor:

Boston Children's Hospital

Code:

NCT03431064

Conditions

Anesthesia

Intravenous Fluid

Blood Pressure

Eligibility Criteria

Sex: All

Age: 0 - 17

Healthy Volunteers: Not accepted

Interventions

Lung Recruitment Maneuver

Fluid Administration

Study Details

Brief summary:

In this research study we want to learn more about using non-invasive tools as a way to predict whether or not a child under general anesthesia will require and respond to fluid administration.

It is important for an anesthesiologist to know if a child would respond to fluid administration so that they can provide the optimal intervention for low blood pressure and avoid unnecessary treatment.

Conditions

Anesthesia

Intravenous Fluid

Blood Pressure

Study ID

NCT03431064

Start date

Jun 21, 2018

Status verified date

Nov, 2025

Completion date

Dec 31, 2027

Anticipated

Primary completion date

Dec 31, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0 - 17

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • 0 to < 18 years old
  • Undergoing surgery at Boston Children's Hospital under general anesthesia
  • mechanically ventilated with an endotracheal tube
  • Monitored with an indwelling radial arterial catheter as part of the anesthetic plan for the scheduled surgical procedure

Exclusion Criteria:

  • Prematurity
  • Low birth weight
  • Congenital heart disease
  • Left or right ventricular dysfunction
  • Cardiac arrhythmia
  • Pulmonary hypertension
  • Preoperative parenchymal or interstitial lung disease
  • Intracranial hypertension
  • Poor transthoracic acoustic window
  • Obesity
  • Allergy to ultrasound transmission gel
  • Need for single lung ventilation
  • Systemic hypertension on antihypertensive medications

Study Design

Enrollment

48 participants

Anticipated

Interventions and Outcome Measures

Arms

Surgical patients less than 18 years old

Patients less than 18 years old having surgery with general anesthesia at Boston Children's Hospital

Interventions

Lung Recruitment Maneuver

Lung Recruitment Maneuver by Anesthesiologist

Fluid Administration

Administration of IV Fluid by Anesthesiologist

Primary outcome measure

  • Change in stroke volume [ Time Frame: immediately before and after each intervention ]

Central Contacts and Locations

Central contacts

Viviane Nasr, MD

617-355-6225viviane.nasr@childrens.harvard.edu

Locations

Boston Children's Hospital

Recruiting

Boston, Massachusetts, United States, 02115

Contacts

Viviane Nasr, MD

617-355-6225viviane.nasr@childrens.harvard.edu

More Information

Sponsor

Boston Children's Hospital

Last update posted

Nov 12, 2025

Last verified

Nov, 2025

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Boston Children's Hospital on 2025-11-12.