Recruiting

Cardiac Rehabilitation

Sponsor:

University of Vermont

Code:

NCT03438968

Conditions

Exercise Training

Coronary Artery Disease

Women

Cardiac Rehabilitation

Eligibility Criteria

Sex: Female

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Exercise training

Study Details

Brief summary:

Cardiovascular disease (CVD) is highly prevalent in women resulting in 398,086 deaths annually. Even as women participate in traditional CR programs, data specificity and subsequent research have yet to emerge in a meaningful way so that women-centered CR can be better customized and their outcomes properly assessed. Aerobic fitness is a powerful predictor of prognosis in individuals with CVD yet there is evidence that women do not improve their peak VO2 as much as men during CR. We have designed a training program for women based upon past research with a goal of optimizing their training potential in CR. This program combines the utilization of a training technique termed high intensity interval training along with specific strength training exercises of the upper legs. We hypothesize that women, irrespective of age, would be capable of high intensity interval training to improve peak aerobic capacity in the CR setting. Furthermore, since women often have a deficit of thigh strength entering CR, and thigh strength correlates with endurance walking,strength training will also be included. The purpose of this study is to examine the value of high intensity interval training and strength training to maximize aerobic training response in CR for women. This may contribute to establishing specific protocols and training guidelines for future program design for women in CR. Since a set of comprehensive CR guidelines pertaining to women is lacking, it is hoped that the results of this study will help us develop exercise protocols and regimen to better structure and modulate CR programs for optimal benefit to women.

Conditions

Exercise Training

Coronary Artery Disease

Women

Cardiac Rehabilitation

Study ID

NCT03438968

Start date

Aug 24, 2017

Status verified date

Feb, 2018

Completion date

Apr 30, 2019

Anticipated

Primary completion date

Dec 31, 2018

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Female

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria: Heart disease, eligible for cardiac rehabilitation -

Exclusion Criteria: Peak VO2 < 12 ml/kg/min

-

Study Design

Enrollment

40 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: High-Intensity aerobic training

Individuals will exercise using a high-intensity interval exercise training protocol

active comparator: Standard Moderate continuous training

Individuals will exercise using a standard moderate intensity continuous exercise training protocol

Interventions

Exercise training

Cardiac Rehabilitation exercise training

Primary outcome measure

  • Aerobic Fitness [ Time Frame: 4-month study participation ]

Central Contacts and Locations

Locations

University of Vermont College of Medicine

Recruiting

Burlington, Vermont, United States, 05401

Principal Investigator:

Philip A Ades, MD

More Information

Sponsor

University of Vermont

Last update posted

Feb 20, 2018

Last verified

Feb, 2018

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Vermont on 2018-02-20.