Recruiting

Genetic Basis

Sponsor:

Jesse Brown VA Medical Center

Code:

NCT03491202

Conditions

Atrial Fibrillation

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

Atrial fibrillation (AF) is reaching epidemic proportions in the aging U.S. and European populations, but the mechanisms of increased susceptibility to atrial fibrillation are still unknown. In this study, we look to further examine genetic and medical co-morbidity influence of atrial fibrillation duration and response to medications. In Specific Aim 1, we propose the creation of a Veterans Affairs AF Biorepository (VAAFBio), which is a resource that will collect and store clinical, demographic, blood and DNA samples from patients with atrial fibrillation to aide this study and future studies of this type in the VA population. In Specific Aim 2, examine common genetic polymorphisms in veteran patients with atrial fibrillation and examine gene-environment interactions with risk factors for atrial fibrillation.

Conditions

Atrial Fibrillation

Study ID

NCT03491202

Start date

May 25, 2017

Status verified date

Jun, 2018

Completion date

May, 2022

Anticipated

Primary completion date

May, 2022

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Subjects must be at least 18 years of age, and up to 100.
  • Subjects must have a documented history of atrial fibrillation by ECG, ECHO, and or Holter monitor event recorder.
  • Subjects must be willing to give written, informed consent.

Exclusion Criteria:

  • Patients with a history of AF or atrial flutter that is only associated with cardiac surgery will be excluded from the study.
  • Subjects who cannot speak English will be excluded from the study.

Study Design

Enrollment

600 participants

Anticipated

Interventions and Outcome Measures

Arms

atrial fibrillation

Patients with a diagnosis of atrial fibrillation will be eligible for enrollment

Primary outcome measure

  • Symptoms related to atrial fibrillation (chest pain, dyspnea, palpitations) [ Time Frame: 1 year ]
  • heart rate [ Time Frame: 1 year ]

Central Contacts and Locations

Central contacts

Katherine A Durham, APN

3125696635Katherine.durham@va.gov

Locations

Jesse Brown VA Medical Center

Recruiting

Chicago, Illinois, United States, 60612

Contacts

Katherine A Durham, MS, APN

312-569-6635Katherine.durham@va.gov

Principal Investigator:

Katherine A Durham, MS, APN

More Information

Sponsor

Jesse Brown VA Medical Center

Last update posted

Jun 11, 2018

Last verified

Jun, 2018

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Jesse Brown VA Medical Center on 2018-06-11.