Recruiting

DNA Methylation

Sponsor:

University of Illinois at Chicago

Code:

NCT03527420

Conditions

Obesity

Vascular Dysfunction

Eligibility Criteria

Sex: All

Age: 18 - 50

Healthy Volunteers: Accepted

Interventions

Exercise training

Study Details

Brief summary:

The main objective is to examine DNA hypomethylation as an underlying mechanism for the increased production of inflammatory cytokines and the impaired vascular function in obese individuals and as a potential target for nonpharmacological preventive/therapeutic interventions such as aerobic exercise.

Conditions

Obesity

Vascular Dysfunction

Study ID

NCT03527420

Start date

Oct 11, 2019

Status verified date

Sep, 2025

Completion date

Aug 31, 2026

Anticipated

Primary completion date

Jun 30, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 50

Healthy Volunteers: Accepted

Inclusion Criteria:

  • BMI ≥ 35 kg/m2
  • Between ages 18-50 years
  • Not pregnant
  • Approved for a bariatric surgery

Exclusion Criteria:

  • To avoid confounding from other inflammatory conditions individuals with current cancer, heart, kidney or liver disease, gallbladder disease or acute or chronic inflammatory diseases (including rheumatoid arthritis, lupus and other autoimmune diseases and genetic diseases) will be excluded
  • Pregnant women will be excluded, as they will not be eligible for bariatric surgery
  • Current smokers
  • Currently abusing alcohol or drugs

Study Design

Enrollment

80 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

active comparator: Exercising

12 weeks of aerobic exercise training

no intervention: Non-exercising

standard of care

Interventions

Exercise training

Twelve weeks of aerobic exercise training

Primary outcome measure

  • DNA methylation status of adipocytokines in obese individuals [ Time Frame: Month 24-30 ]

Central Contacts and Locations

Central contacts

Abeer Mohamed, MD, PhD

3127539998amahmo4@uic.edu

Locations

University of Illinois at Chicago

Recruiting

Chicago, Illinois, United States, 60612

Contacts

Abeer M Mohamed, MD, PhD

312-355-8099amahmo4@uic.edu

More Information

Sponsor

University of Illinois at Chicago

Last update posted

Sep 15, 2025

Last verified

Sep, 2025

Keywords

  • Obesity
  • DNA methylation
  • Exercise
  • Weight loss
  • Bariatric
  • Macrovascular
  • Microvascular
  • Epigenetics
  • Adipose tissue
  • Adipocytokines
  • Inflammation
  • Cardiovascular

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by University of Illinois at Chicago on 2025-09-15.