Recruiting
Phase 2

High-Velocity Resistance Training & Creatine

Sponsor:

University of Regina

Code:

NCT03530202

Conditions

Sarcopenia

Eligibility Criteria

Sex: Male

Age: 50+

Healthy Volunteers: Accepted

Interventions

Creatine monohydrate

Maltodextrin Powder

Study Details

Brief summary:

The age-related loss of skeletal muscle mass (i.e. sarcopenia)and muscle performance (i.e. strength and power), decreases functionality and the ability to perform activities of daily living. Therefore, lifestyle interventions which may improve aging muscle health are important (i.e. resistance training and creatine supplementation). High-velocity resistance training (HVRT) has been shown to increase muscle mass and muscle performance in aging adults. Creatine (CR), a compound naturally found in red meat and seafood, has also been shown to increase muscle mass and muscle performance in aging adults. No study has examined the combined effects of HVRT and CR supplementation in aging adults. This study may determine whether this lifestyle intervention is effective to combat sarcopenia.

Conditions

Sarcopenia

Study ID

NCT03530202

Start date

Jan 1, 2018

Status verified date

May, 2018

Completion date

Jul 31, 2018

Anticipated

Primary completion date

Jul 31, 2018

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Male

Age: 50+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Males (≥ 50 years) who are not engaged in supervised resistance training for ≥ 6 weeks prior to the start of the study will be recruited to participate.

Exclusion Criteria:

  • Participants will be excluded if they have taken medications that affect muscle biology or creatine monohydrate ≤ 12 weeks prior to the start of the study
  • If they have a history of fragility fractures; diseases that are known to affect muscle biology (i.e. corticoids)
  • If they suffer from severe osteoarthritis
  • If they are currently participating in moderate-vigorous resistance training (≥ 3 times per week)
  • If they are vegetarian
  • If they are planning to travel during the study period for greater than 2 weeks duration at a time.
  • Participants with kidney or liver abnormalities will be excluded.

Study Design

Enrollment

40 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

experimental: HVRT + Creatine Monohydrate

Participants will perform 8-weeks of high-velocity resistance training, defined as performing the concentric phase of a lift as fast as possible and taking two seconds to perform the eccentric phase of the lift, on six exercises (bilateral legpress, leg extension, leg curl, chest press, triceps extension, and biceps curl) and consume creatine monohydrate powder. The load will be 80% of the participants one-repetition max (1RM; the maximum weight that can be successfully lifted one time with proper form).

placebo comparator: HVRT + Maltodextrin Powder

Participants will perform 8-weeks of high-velocity resistance training, defined as performing the concentric phase of a lift as fast as possible and taking two seconds to perform the eccentric phase of the lift, on six exercises (bilateral legpress, leg extension, leg curl, chest press, triceps extension, and biceps curl) and consume maltodexterin powder. The load will be 80% of the participants one-repetition max (1RM; the maximum weight that can be successfully lifted one time with proper form).

Interventions

Creatine monohydrate

Participants will consume creatine monohydrate powder (Creapure, AlzChem AG, Trostberg, Germany) every day for 8 weeks. On training days participants will consume supplement immediately after each training session (\~ 5 minutes) mixed in water as post-exercise creatine ingestion enhances its uptake into muscle and promotes increased muscle mass. On non-training days, supplements will be consumed at the participant's leisure.

Maltodextrin Powder

Participants will consume Maltodextrin Powder (Globe Plus 10 DE Maltodextrin Powder, Univar Canada) every day for 8 weeks. On training days participants will consume supplement immediately after each training session (\~ 5 minutes) mixed in water. On non-training days, supplements will be consumed at the participant's leisure.

Primary outcome measure

  • Change in muscle thickness [ Time Frame: Baseline and again once intervention is completed (8 weeks) ]

Central Contacts and Locations

Central contacts

Darren G Candow, PhD

(306) 585-4906Darren.Candow@uregina.ca

John P Neary, PhD

(306) 585-4844Patrick.Neary@uregina.ca

Locations

University of Regina

Recruiting

Regina, Saskatchewan, Canada, S4S4J5

Principal Investigator:

Darren G Candow, PhD

More Information

Sponsor

University of Regina

Last update posted

May 21, 2018

Last verified

May, 2018

Keywords

  • muscle thickness
  • strength
  • power
  • functionality

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Regina on 2018-05-21.