Recruiting

Anesthesia

Sponsor:

Memorial Sloan Kettering Cancer Center

Code:

NCT03546387

Conditions

Pediatric Retinoblastoma

Retinoblastoma

Eligibility Criteria

Sex: All

Age: 6 - 17

Healthy Volunteers: Not accepted

Interventions

Wechsler Intelligence Scale for Children, Fifth Edition (WISC-V)

California Verbal Learning Test, Children's Version

Beery Developmental Test of Visual Motor Integration, 6th edition

Grooved Pegboard Test

Behavior Assessment System for Children/Parent Report

Study Details

Brief summary:

The purpose of this study is to see if there is a difference between the development of the brain (neurodevelopment) in children who have been treated for retinoblastoma with multiple anesthetic exposures, compared with brain development in children who have never had anesthesia.

Conditions

Pediatric Retinoblastoma

Retinoblastoma

Study ID

NCT03546387

Start date

May 7, 2018

Status verified date

Jun, 2026

Completion date

May 7, 2027

Anticipated

Primary completion date

May 7, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 6 - 17

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Age ≥ 6 and < 17 years old

Exclusion Criteria:

  • Diagnosis of any secondary disease associated with developmental delay
  • History of second cancer diagnosis
  • Legal Blindness
  • Past surgery of any type, with the exception of enucleation for retinoblastoma
  • Past exposure to anesthesia for surgical intervention
  • More than one anesthesia encounter for surgical intervention before diagnosis at MSK
  • Past External Beam Radiation for treatment of retinoblastoma
  • Past systemic chemotherapy
  • Non-native speaker of English; however, children whose parents speak only Spanish will be included, because the tests for parents are available in Spanish

Study Design

Enrollment

75 participants

Anticipated

Interventions and Outcome Measures

Interventions

Wechsler Intelligence Scale for Children, Fifth Edition (WISC-V)

the WISC-V assessment produces a Full Scale IQ (FSIQ) used for primary power consideration in this study. The FSIQ is the most comprehensive global ability score on the WISC-V, and it has been conventionally reported and interpreted as an estimation of overall intellectual ability

California Verbal Learning Test, Children's Version

Used to assess verbal learning and memory in children and adolescents

Beery Developmental Test of Visual Motor Integration, 6th edition

Helps assess visual-motor skills in children and adults.

Grooved Pegboard Test

Measures dexterity

Behavior Assessment System for Children/Parent Report

The Behavior Assessment System for Children/Parent Report is a questionnaire that assesses the social-emotional and behavioral functioning (e.g., anxiety, depression, attention, hyperactivity, adaptability, leadership, social skills, etc.) in children between the ages of 2 and 22 years, and is available in English and Spanish.

Primary outcome measure

  • Comparing scores in neuropsychological testing results [ Time Frame: 6 weeks ]

Central Contacts and Locations

Central contacts

Vittoria Arslan Carlon, MD

212-639-2680arslancv@mskcc.org

David Abramson, MD

212-639-7232abramsod@mskcc.org

Locations

Memorial Sloan Kettering Cancer Center

Recruiting

New York, New York, United States, 10065

Contacts

Vittoria Arslan Carlon, MD

212-639-2680

More Information

Sponsor

Memorial Sloan Kettering Cancer Center

Last update posted

Jun 3, 2026

Last verified

Jun, 2026

Keywords

  • 18-126
  • Memorial Sloan Kettering Cancer Center

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Memorial Sloan Kettering Cancer Center on 2026-06-03.