Recruiting

Observational Study

Sponsor:

University Health Network, Toronto

Code:

NCT03582189

Conditions

Magnetic Resonance Imaging

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

MRI

Study Details

Brief summary:

This is a single centre, single arm, prospective feasibility study that aims to see whether magnetic resonance imaging (MRI) as a source of image guidance before each radiation treatment fraction is feasible, and also if it may provide information that could potentially be used during the treatment to improve the radiation treatment plan.

Patients will have 5 MRIs with each of their RT sessions. If patients' RT treatment will consist of more than 5 fractions, only 5 MRIs will be done with any 5 RT fractions. Patients will be completing a short questionnaire at the end of each MRI. A patient questionnaire will also be completed at the end of the study to assess for patient satisfaction.

There will be 30 evaluable patients enrolled to the study.

Conditions

Magnetic Resonance Imaging

Study ID

NCT03582189

Start date

Jul 11, 2018

Status verified date

Mar, 2026

Completion date

Feb, 2027

Anticipated

Primary completion date

Feb, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Patients 18 years or older
  • Diagnosed with locally advanced pancreatic cancer or hepatocellular carcinoma being considered for treatment with chemoradiation, long course RT, or SBRT with curative intent or palliative intent, planned for 5 or more RT fractions

Exclusion Criteria:

\- Contraindications for MRI: ferromagnetic prosthesis, pacemaker / implanted defibrillator, claustrophobia

Study Design

Enrollment

30 participants

Anticipated

Interventions and Outcome Measures

Arms

Pancreatic Cancer

Approximately 10 patients with pancreatic cancer will be enrolled to the study with the primary aim of determining the feasibility of using off-line MRI-guidance during the course of radiation treatment

Liver Metastases

Approximately 10 patients with liver mets will be enrolled to the study with the primary aim of determining the feasibility of using off-line MRI-guidance during the course of radiation treatment

Hepatocellular carcinoma

Approximately 10 patients with HCC will be enrolled to the study with the primary aim of determining the feasibility of using off-line MRI-guidance during the course of radiation treatment

Interventions

MRI

Patients who consent to this study will have an abdominal MRI prior to or immediately after each fraction of radiation treatment in the case of those patients that are undergoing SBRT or those receiving palliative treatment. On patients receiving definitive chemoradiation, an abdominal MRI will be performed prior to or immediately after radiation treatment once per week during the any five weeks of treatment

Primary outcome measure

  • Patient Satisfaction Survey [ Time Frame: At study completion (day5 or week 5, depending on type of treatment) ]
  • MRI-Anxiety Questionnaire [ Time Frame: Prior to or before MR session 1 (day 1 or week 1, depending on type of treatment) ]
  • MRI-Anxiety Questionnaire [ Time Frame: Prior to or before MR session 2 (day 2 or week 2, depending on type of treatment) ]
  • MRI-Anxiety Questionnaire [ Time Frame: Prior to or before MR session 3 (day 3 or week 3, depending on type of treatment) ]
  • MRI-Anxiety Questionnaire [ Time Frame: Prior to or before MR session 4 (day 4 or week 4, depending on type of treatment) ]
  • MRI-Anxiety Questionnaire [ Time Frame: Prior to or before MR session 5 (day 5 or week 5, depending on type of treatment) ]

Central Contacts and Locations

Central contacts

Edel Sexton

416-946-4501Edel.Sexton@uhn.ca

Jana Huang

Jana.Huang@uhnresearch.ca

Locations

University Health Network - Princess Margaret Cancer Centre

Recruiting

Toronto, Ontario, Canada, M5G 2M9

More Information

Sponsor

University Health Network, Toronto

Last update posted

Mar 5, 2026

Last verified

Mar, 2026

Keywords

  • Liver Cancer
  • Pancreatic Cancer
  • Radiation

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University Health Network, Toronto on 2026-03-05.