Recruiting

Observational Study

Sponsor:

Yale University

Code:

NCT03592290

Conditions

Hypovolemia

Hemodynamic Instability

Eligibility Criteria

Sex: All

Age: 20 - 45

Healthy Volunteers: Accepted

Interventions

Lower body negative pressure

Study Details

Brief summary:

To monitor the changes in central and peripheral monitors/waveforms during gradual hypovolemia induced by lower body negative pressure in healthy volunteers.

Conditions

Hypovolemia

Hemodynamic Instability

Study ID

NCT03592290

Start date

Nov 15, 2017

Status verified date

Jan, 2026

Completion date

Jan, 2027

Anticipated

Primary completion date

Jan, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 20 - 45

Healthy Volunteers: Accepted

Inclusion Criteria:

\* Healthy volunteers aged 20-45 with

Exclusion Criteria:

  • Pregnant women
  • Under 20 years of age
  • Subjects with coronary artery disease, diabetes, epilepsy and hypertension

Study Design

Enrollment

120 participants

Anticipated

Interventions and Outcome Measures

Interventions

Lower body negative pressure

We will be monitoring the changes in central and peripheral monitors/waveforms during gradual hypovolemia induced by lower body negative pressure in healthy volunteers.

Primary outcome measure

  • Identify the most robust site for monitoring hypovolemia utilizing pulse oximeter waveforms. [ Time Frame: 2 years ]

Central Contacts and Locations

Central contacts

Aymen Alian, MD

203-785-2802aymen.alian@yale.edu

Locations

John B. Pierce Laboratory

Recruiting

New Haven, Connecticut, United States, 06520

Contacts

Aymen A Alian

203-785-2802aymen.alian@yale.edu

More Information

Sponsor

Yale University

Last update posted

Jan 20, 2026

Last verified

Jan, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Yale University on 2026-01-20.