Negative Pressure Wound Therapy vs. Sterile DressingNegative Pressure Wound Therapy vs. Sterile Dressing for Patients Undergoing Thoracolumbar Spine Surgery

Inclusion Criteria: Patients who meet the following criteria are eligible for admission into the study:

• Require spine surgery with a posterior midline incision that involves the thoracic, lumbar and/or sacral spine
• Capable of and agree to consent and randomization
• Be in one of the following clinical presentation groups:

1. Metastic tumor of the thoracic or lumbar spine (T1-S5), requiring instrumentation and decompression, with or without pre-operative radiation to surgical site
2. Thoracolumbar degeneration or deformity (T1-S5) with index surgery >6 months prior, requiring revision surgery with additional instrumentation
3. Acute traumatic thoracolumbar (T1-L5) fracture(s) with neurological deficit (AIS A-C), requiring instrumentation and decompression

All study participants will remain in hospital for a minimum of 7 days post-op as per standard of care. As a result, the full duration of application of the Prevena dressing will take place in hospital.

Exclusion Criteria: patients who fulfill any of the following criteria are not eligible for admission into the study:

• Undergoing percutaneous surgery
• Active Surgical Site Infection (SSI) or primary spinal column infection or distant site infection (urinary tract, respiratory tract, etc.) at time of admission
• Pregnancy

The following are clinical scenarios that would mandate the patients' exclusion from final analysis:

• Failure to complete the 6-week clinical follow-up (Lost to Follow Up)
• Second surgery required, at the same anatomical site, during study time period (six weeks), for causes other than primary (SSI) or secondary (dehiscence, seroma) study endpoints