BasisTMBasis: Evaluating Sirtuin Supplements To Benefit Elderly Trauma Patients (BES2T BET)

Inclusion Criteria:

1. ≥ 65 year old
2. Patient presenting to trauma bay

Exclusion Criteria:

1. Currently taking medication for severe to moderate dementia (see Appendix 9)
2. Currently taking niacin, nicotinic acid, nicotinamide, or nicotinamide riboside
3. Pre-existing immobility (wheel chair or bed bound)
4. Renal failure requiring hemodialysis or peritoneal dialysis
5. End-stage Liver Disease (Model for End Stage Liver Disease Score ≥ 25) (see Appendix 11)
6. Intubated prior to enrollment (excluding intubation for surgery)
7. More than 48 hours post-injury
8. Thoracic Anatomic Injury Score > 3 (see Appendix 10)
9. Other Injuries with Anatomic Injury Score >2, excluding thorax (see Appendix 10)
10. Hip fractures
11. Non-English speaking