Recruiting

Observational Study

Sponsor:

The University of Texas Health Science Center at San Antonio

Code:

NCT03655015

Conditions

Lung Neoplasm

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Lung Tumor Resection

Study Details

Brief summary:

Create a living biobank of PDOs from Stage I-III lung cancer patients.

Conditions

Lung Neoplasm

Study ID

NCT03655015

Start date

Oct 16, 2018

Status verified date

Apr, 2026

Completion date

Dec 1, 2029

Anticipated

Primary completion date

Dec 1, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Read, consented to and signed the IRB-approved informed consent form prior to any study related procedure.
  • Diagnosis of lung cancer or lung mass or lymphadenopathy that will either systemic treatment or tumor resection as part of standard of care
  • Any clinical stage of lung cancer
  • Adult patients ≥18 years of age
  • Able and willing to complete a questionnaire on their environmental/occupational exposures and smoking/alcohol history

Exclusion Criteria:

  • At the discretion of the treating physician, patient will not be able to fulfill the requirements of the study.

Study Design

Enrollment

150 participants

Anticipated

Interventions and Outcome Measures

Interventions

Lung Tumor Resection

Lung Tumor Resection

Primary outcome measure

  • To establish and characterize a biobank of patient-derived organoids (PDOs), and investigate the potential of PDOs to recapitulate ex vivo responses to chemotherapeutic and targeted agents observed in the clinic. [ Time Frame: 10 years ]

Central Contacts and Locations

Central contacts

Josephine Taverna, MD

210-450-8234tavernaj@uthscsa.edu

Locations

UT Health San Antonio, M.D. Anderson Cancer Center

Recruiting

San Antonio, Texas, United States, 78229

Contacts

Research Office

210-450-1000mccresearch@uthscsa.edu

Principal Investigator:

Josephine Taverna, MD

More Information

Sponsor

The University of Texas Health Science Center at San Antonio

Last update posted

Apr 20, 2026

Last verified

Apr, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by The University of Texas Health Science Center at San Antonio on 2026-04-20.