Recruiting

Optical Coherence Tomography

Sponsor:

Ohio State University Comprehensive Cancer Center

Code:

NCT03711890

Conditions

Pancreatic Carcinoma

Pancreatic Intraductal Papillary Mucinous Neoplasm, Pancreatobiliary-Type

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Optical Coherence Tomography

Therapeutic Conventional Surgery

Laboratory Evaluation

Study Details

Brief summary:

This trial studies how well ultra-high resolution optical coherence tomography works in detecting micrometer sized early stage pancreatic cancer in participants with pancreatic cancer. Ultra-high resolution optical coherence tomography may help to accurately identify pancreatic cancer in resected pancreatic specimens.

Conditions

Pancreatic Carcinoma

Pancreatic Intraductal Papillary Mucinous Neoplasm, Pancreatobiliary-Type

Study ID

NCT03711890

Start date

Mar 26, 2019

Status verified date

Jun, 2026

Completion date

Sep 15, 2026

Anticipated

Primary completion date

Sep 15, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Immediate surgery cohort: Adult patients with pancreatic cancer or IPMN
  • Immediate surgery cohort: Informed consent will be obtained
  • Adult patients undergoing pancreatic resection for a presumed IPMN

Exclusion Criteria:

  • Pregnant

Study Design

Enrollment

75 participants

Anticipated

Intervention Model

Single group

Primary purpose

Diagnostic

Interventions and Outcome Measures

Arms

experimental: Diagnostic (resection, OCT)

Participants undergo resection. Resected tissues are analyzed via ultra-high resolution OCT.

Interventions

Optical Coherence Tomography

Undergo OCT

Therapeutic Conventional Surgery

Undergo resection will be undertaken

Laboratory Evaluation

Labs will be obtained to test for cancer cell derived exosomes

Primary outcome measure

  • Measure accuracy of using OCT to diagnose pancreatic cancer and compare with histology. [ Time Frame: Up to 3 years ]

Central Contacts and Locations

Central contacts

Ohio State University Comprehensive Cancer Center

800-293-5066OSUCCCClinicaltrials@osumc.edu

Locations

Ohio State University Comprehensive Cancer Center

Recruiting

Columbus, Ohio, United States, 43210

Contacts

Mary E. Dillhoff, MD

614-293-7171Mary.Dillhoff@osumc.edu

Principal Investigator:

Mary E. Dillhoff, MD

More Information

Sponsor

Ohio State University Comprehensive Cancer Center

Last update posted

Jun 15, 2026

Last verified

Jun, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Ohio State University Comprehensive Cancer Center on 2026-06-15.