Recruiting

Observational Study

Sponsor:

Unity Health Toronto

Code:

NCT03713853

Conditions

Acetabular Fracture

Eligibility Criteria

Sex: All

Age: 60+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

Management of acetabular (hip) fractures in the geriatric population can be very challenging because of pre-existing medical comorbidities, pre-existing osteoporosis and increased risk of mortality.

The two most common treatment options for acetabular fractures are either surgical fixation using plates and screws to hold the fractured pieces in the correct position until the fracture has healed or surgical fixation in addition to a total hip replacement.

Surgical fixation requires prolonged immobilization of the affected limb (typically around 6-12 weeks post-operatively), which can lead to disability and other complications. Such patients, especially those who are frail and cognitively impaired, are unable to adhere to the immobilization restrictions, leading to an increased risk of fixation failure.

Patients who underwent open reduction internal fixation (ORIF) of an acetabular fracture were reported to have about 25 times greater incidence of hip replacement compared with general population matched controls.

Additionally, performing a subsequent hip replacement after a previous surgical fixation (ORIF) of an acetabular fracture, especially in the elderly population, can present a number of technical difficulties including; difficult dissection due to previous incision(s) and scarring, dealing with retained hardware, bony deficiency and the possibility of infected hardware.

The aim of the study is to perform a large cohort study to assess pain and physical function in patients 60 years and older who have sustained an acetabular fracture.

Conditions

Acetabular Fracture

Study ID

NCT03713853

Start date

Dec, 2026

Status verified date

Apr, 2026

Completion date

Dec, 2030

Anticipated

Primary completion date

Dec, 2029

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 60+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • 60 years of age or older
  • Isolated and Displaced (more or equal to 2mm on any radiographic view) fracture of the acetabulum
  • Patient requires surgical treatment, either THA+ORIF or ORIF surgeries
  • Fracture is acute (within 3 weeks of injury)
  • Patient was ambulatory (with or without walking aids) prior to their acetabular fracture injury
  • Patient is able to provide informed consent to participation in the study
  • Patient is able to read and understand English

Exclusion Criteria:

  • Presence of an active or chronic infection around the fracture (soft tissue or bone)
  • Open/compound fracture
  • Bilateral acetabular fractures
  • Pathological fracture excluding osteoporosis
  • Periprosthetic fracture (previous arthroplasty or hardware or ORIF in-situ). Hardware (screws or plates or nails or hemi-arthroplasty) on the femoral side are not excluded.
  • Medical or surgical contraindication to surgery
  • Dementia

Study Design

Enrollment

104 participants

Anticipated

Interventions and Outcome Measures

Arms

Total hip arthroplasty + ORIF

Patients will receive acute primary total hip arthroplasty (THA) with open reduction internal fixation (ORIF) as a treatment for their acetabular fracture

Surgical Fixation (ORIF)

Patients will receive open reduction internal fixation (ORIF) as a treatment for their acetabular fracture

Primary outcome measure

  • Oxford Hip score [ Time Frame: Questionnaire will be completed by patients at 3, 6 and 12-months follow-up and repeated measures analysis will be performed to assess the change across all time points (3,6 and 12-months) ]

Central Contacts and Locations

Central contacts

Locations

Unity Health Toronto - St Michael's Hospital

Recruiting

Toronto, Ontario, Canada, M5C 1R6

Contacts

More Information

Sponsor

Unity Health Toronto

Last update posted

Jun 12, 2026

Last verified

Apr, 2026

Keywords

  • Total hip replacement
  • Total hip arthroplasty
  • Open Reduction internal Fixation
  • Hip fixation

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Unity Health Toronto on 2026-06-12.