Recruiting

Observational Study

Sponsor:

University of Pittsburgh

Code:

NCT03759717

Conditions

Skull Base Neoplasm

Cellular Pathology

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Not accepted

Interventions

Observation

Study Details

Brief summary:

The purpose of the study is to analyze biological samples and genetic material for basic science research investigating the molecular and cellular characterization of skull base tumors.

Conditions

Skull Base Neoplasm

Cellular Pathology

Study ID

NCT03759717

Start date

Oct 3, 2018

Status verified date

Sep, 2025

Completion date

Oct 3, 2028

Anticipated

Primary completion date

Oct 3, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Diagnosis of a skull base tumor

Exclusion Criteria:

  • Insufficient tumor sample at time of resection

Study Design

Enrollment

4000 participants

Anticipated

Interventions and Outcome Measures

Interventions

Observation

Understanding the biology of skull base tumors will teach the investigators about the genesis and/or mechanisms of treatment resistance. The investigators hope to ultimately identify new targets which will add to the armamentarium by which to treat these tumors.

Primary outcome measure

  • Patient overall survival will be measured and reported. [ Time Frame: Through study completion, an average of 10 years ]

Central Contacts and Locations

Central contacts

Benita Valappil, MPH

412-864-1744valappilb2@upmc.edu

Locations

University of Pittsburgh Medical Center

Recruiting

Pittsburgh, Pennsylvania, United States, 15213

Contacts

Benita Valappil, MPH

412-864-1744valappilb2@upmc.edu

More Information

Sponsor

University of Pittsburgh

Last update posted

Sep 22, 2025

Last verified

Sep, 2025

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Pittsburgh on 2025-09-22.