Recruiting

Branched-chain Amino Acids

Sponsor:

Western University, Canada

Code:

NCT03766815

Conditions

Muscle Damage

Eligibility Criteria

Sex: All

Age: 18 - 40

Healthy Volunteers: Accepted

Interventions

BCAA 200mg/kg/day

Placebo

BCAA 400mg/kg/day

Muscle damaging exercise

Study Details

Brief summary:

Seventy-eight recreational athletes who never resistance trained will be randomly assigned into three groups of twenty-six. Branched-chain amino acid will be supplemented for 18days at 0, 200 or 400 mg/body weight(kg)/day in jelly. Participants will be asked to perform elbow flexions on the 12th day of supplementation. Maximum voluntary contractions will be measured before, during and after the supplementation period to compare the effects of different doses of branched-chain amino acid has on muscle damage markers.

Conditions

Muscle Damage

Study ID

NCT03766815

Start date

Oct 1, 2019

Status verified date

Sep, 2019

Completion date

Dec 31, 2019

Anticipated

Primary completion date

Dec 31, 2019

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 40

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Healthy males and females at the age of 18-40
  • Endurance trained athletes
  • Weekly exercise duration is less than 150minutes but more than 30 minutes

Exclusion Criteria:

  • Individuals who cannot endure three days for not eating meat
  • Diabetic
  • Have been performing resistance trainings
  • Have been taking protein supplement
  • Have been consuming a high level of protein in the regular diet
  • Have been taking omega-three and vitamin E supplements
  • Have been taking anabolic Steroids
  • Have been taking regular medications
  • Have cardiovascular Disease
  • Have a history of joint \& Muscle Injuries
  • Females with irregular Menstrual Cycle

Study Design

Enrollment

78 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Other

Interventions and Outcome Measures

Arms

placebo comparator: Placebo

Fiber supplement mixed with jelly will be ingested for 18 days with participants performing elbow eccentric contractions as a muscle damaging exercise on the 12th-day of supplementation.

experimental: BCAA 200mg/kg/day

Branched-chain amino acid supplement mixed with jelly will be ingested for 18 days. The amount of supplement provided will be based on body weight (200mg/kg/day) with participants performing elbow eccentric contractions as a muscle damaging exercise on the 12th-day of supplementation.

experimental: BCAA 400mg/kg/day

Branched-chain amino acid supplement mixed with jelly will be ingested for 18 days. The amount of supplement provided will be based on body weight (400mg/kg/day) with participants performing elbow eccentric contractions as a muscle damaging exercise on the 12th-day of supplementation.

Interventions

BCAA 200mg/kg/day

BCAA supplement based on 200mg/kg/day for 18 days.

Placebo

Fiber supplement jelly for 18 days.

BCAA 400mg/kg/day

BCAA supplement based on 400mg/kg/day for 18 days.

Muscle damaging exercise

Participants will be asked to perform muscle damaging elbow eccentric contraction exercise at 120% of 1RM for three sets of 15 repetitions with the dominant arm at maximal effort on a Biodex machine with a 3 minute rest period between each set.

Primary outcome measure

  • Change in maximum voluntary contraction (MVC) [ Time Frame: baseline (before supplementation) and at 1,3,24,48,72,96,120,144 hours after muscle damage ]

Central Contacts and Locations

Central contacts

Crystal Lee, BSc

519 6612111plee263@uwo.ca

Arash Bandegan, PhD

519 6612111abandeg@uwo.ca

Locations

Exercise Nutrition Laboratory (Western University)

Recruiting

London, Ontario, Canada, N6A 3K7

Contacts

Peter Lemon, PhD

519 6612111plemon@uwo.ca

More Information

Sponsor

Western University, Canada

Last update posted

Oct 2, 2019

Last verified

Sep, 2019

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Western University, Canada on 2019-10-02.