Recruiting

Emotional Memory

Sponsor:

Beth Israel Deaconess Medical Center

Code:

NCT03767426

Conditions

Sleep Deprivation

Sleep

Eligibility Criteria

Sex: All

Age: 18 - 35

Healthy Volunteers: Accepted

Interventions

Sleep Deprivation

Daytime nap

Study Details

Brief summary:

To further understand the impact of acute sleep deprivation and recovery sleep on the processing of emotional information the investigators will address and attempt to answer three questions, (i) how both undisturbed sleep and sleep deprivation affect the processing and retrieval of emotional information, (ii) what neural and psychophysiological mechanisms are associated with these behavioral effects, and (iii) to explore the ability of recovery sleep to reverse the effects of sleep deprivation. Together, these studies will provide a greater breadth and depth of knowledge concerning sleep's role in emotion processing and regulation. Given the growing societal tendency to view sleep as unproductive-foregoing it to lengthen work days and increase social opportunities- such knowledge would be of practical importance for understanding the role of sleep in healthy emotional functioning, particular for individuals experiencing periods of increased stress and emotional distress (e.g., new parents, hospital staff, or combat troops).

Conditions

Sleep Deprivation

Sleep

Study ID

NCT03767426

Start date

Mar 1, 2019

Status verified date

Aug, 2024

Completion date

Dec 31, 2025

Anticipated

Primary completion date

Dec 31, 2025

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 35

Healthy Volunteers: Accepted

Inclusion Criteria:

  • willing and able to follow the protocol
  • willing and able to meet inclusion criteria for fMRI scanning
  • willing to refrain from alcohol and recreational drugs for the duration of the protocol
  • normal or corrected to normal vision is required

Exclusion Criteria:

  • self-reported sleep disturbances
  • left-handedness or ambidexterity
  • a history of mental illness or neurological disorder
  • the use of any drugs that could affect either sleep or cognitive functioning (e.g., sleeping pills or antidepressants)

Study Design

Enrollment

100 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

no intervention: Overnight sleep

Subjects are permitted a night of polysomnograph-recorded sleep before participating in training and testing sessions the next day

active comparator: Sleep deprivation

Subjects sleep deprived before participating in training and testing sessions the next day

experimental: Daytime Nap

Subjects are trained and then retested after a daytime nap

Interventions

Sleep Deprivation

Subjects are sleep deprived for an entire night

Daytime nap

After a night of sleep deprivation, participants will be given a 2 hour nap opportunity

Primary outcome measure

  • Morphed Face Accuracy and Intensity [ Time Frame: 1-24 hours ]
  • Emotional Memory Tradeoff Memory Score [ Time Frame: 12-24 hours ]
  • Psychomotor vigilance task lapse rate [ Time Frame: 1-24 hours ]

Central Contacts and Locations

Central contacts

Locations

Tony Cunningham

Recruiting

Boston, Massachusetts, United States, 02215

Contacts

More Information

Sponsor

Beth Israel Deaconess Medical Center

Last update posted

Aug 6, 2024

Last verified

Aug, 2024

Keywords

  • Emotion
  • Memory
  • Sleep
  • Sleep Deprivation

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Beth Israel Deaconess Medical Center on 2024-08-06.