Recruiting

Observational Study

Sponsor:

University of Calgary

Code:

NCT03786263

Conditions

Nephrotic Syndrome in Children

Nephrotic Syndrome, Minimal Change

Nephrotic Syndrome，Idiopathic

Eligibility Criteria

Sex: All

Age: 1 - 17

Healthy Volunteers: Not accepted

Study Details

Brief summary:

CHILDNEPH is a pan-Canadian project to observe clinical care for children with nephrotic syndrome. Previous studies have indicated that there is wide practice variation in how health care providers treat this remitting and relapsing disease of childhood. The disease mechanism is not yet understood, and long-term use of steroids can affect children's health. This study involves assessment of routine clinical care and establishing a long-term patient registry for children with nephrotic syndrome.

Conditions

Nephrotic Syndrome in Children

Nephrotic Syndrome, Minimal Change

Nephrotic Syndrome，Idiopathic

Study ID

NCT03786263

Start date

Aug 3, 2014

Status verified date

May, 2019

Completion date

Mar 31, 2022

Anticipated

Primary completion date

Jun 30, 2020

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 1 - 17

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Diagnosis with Nephrotic Sydrome at initial presentation, first or second relapse

Exclusion Criteria:

  • unable to participate in English or French
  • Nephrotic Syndrome is secondary to other disease
  • Younger than one year old or older than 17 years

Study Design

Enrollment

400 participants

Anticipated

Interventions and Outcome Measures

Arms

Prospective Treatments for NS

Observation of children (between the ages of 1 and 17) who are diagnosed with Nephrotic Syndrome at their initial presentation, first or second relapse.

Observation of children who receive Glucocorticoids to treat Nephrotic Syndrome.

Observation of children who receive other drugs (Second Line Agents) for Nephrotic Syndrome.

Primary outcome measure

  • Association of steroid dose prescribed with relapse rates [ Time Frame: 30 months up to 90 months ]

Central Contacts and Locations

Central contacts

Laurel Ryan, MFA

403-955-7160laurel.ryan@ahs.ca

Maneka Perinpanayagam, PhD

403-955-2467maneka.perinpanayagam@ahs.ca

Locations

Alberta Children's Hospital

Recruiting

Calgary, Alberta, Canada, T3B 6A8

Contacts

Laurel Ryan, MFA

403-955-7160laurel.ryan@ahs.ca

Maneka Perinpanayagam, PhD

403-955-2467maneka.perinpanayagam@ahs.ca

Principal Investigator:

Susan Samuel, MD MSc

Stollery Children's Hospital, University of Alberta

Recruiting

Edmonton, Alberta, Canada, T6G 2B7

Contacts

Catherine Morgan, MD

cmorgan@ualberta.ca

British Columbia Children's Hospital

Recruiting

Vancouver, British Columbia, Canada, V6H 3V4

Contacts

Cherry Mammen, MD

604-875-2345cmammen@cw.bc.ca

Allison Eddy, MD

604-875-2345allison.eddy@cw.bc.ca

Winnipeg Children's Hospital, University of Manitoba

Recruiting

Winnipeg, Manitoba, Canada, R3A 1S1

Contacts

Allison Dart, MD

adart@hsc.mb.ca

Maury Pinsk, MD

mpinsk@hsc.mb.ca

IWK Health Centre

Recruiting

Halifax, Nova Scotia, Canada, B3H 1V7

McMaster Children's Hospital

Recruiting

Hamilton, Ontario, Canada, L8N 3Z5

Contacts

Steve Arora, MD

arorast@mcmaster.ca

Rahul Chanchlani, MD

chanchlr@mcmaster.ca

Children's Hospital, London Health Sciences Centre

Recruiting

London, Ontario, Canada, N6A 5W9

Contacts

Guido Filler, MD

guido.filler@lhsc.on.ca

Children's Hospital of Eastern Ontario (CHEO) University of Ottawa

Recruiting

Ottawa, Ontario, Canada, K1H 8L1

Contacts

Pavel Geier, MD

pgeier@cheo.on.ca

Janusz Feber, MD

jfeber@cheo.on.ca

The Hospital for Sick Children (SickKids)

Recruiting

Toronto, Ontario, Canada, M5G 1X8

Contacts

Rulan Parekh, MD

rulan.parekh@sickkids.ca

CHU Ste. Justine

Recruiting

Montréal, Quebec, Canada, B3H 1V7

Contacts

Genevieve Benoit, MD

514-345-4931genevieve.benoit.hsj@ssss.gouv.qc.ca

Anne-Laure Lapeyraque, MD

514-345-4931anne-laure.lapeyraque.hsj@ssss.gouv.qc.ca

Montreal Children's Hospital - McGill University

Recruiting

Montréal, Quebec, Canada, H4A 3J1

Contacts

Beth Foster, MD

beth.foster@muhc.mcgill.ca

Royal University Hospital, University of Saskatchewan

Recruiting

Saskatoon, Saskatchewan, Canada, S7N 0W8

Contacts

Robin Erickson, MD

robin.erickson@usask.ca

More Information

Sponsor

University of Calgary

Last update posted

May 6, 2019

Last verified

May, 2019

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Calgary on 2019-05-06.