Recruiting

Hormones & Aging

Sponsor:

Mayo Clinic

Code:

NCT03821857

Conditions

Alzheimer Disease

Eligibility Criteria

Sex: Female

Age: 60+

Healthy Volunteers: Accepted

Interventions

18-F-Flortaucipir

Study Details

Brief summary:

The researchers are trying to determine whether ovarian hormones are associated with aging processes and with the risk of developing Alzheimer's disease in women.

Conditions

Alzheimer Disease

Study ID

NCT03821857

Start date

Jun 27, 2019

Status verified date

Nov, 2025

Completion date

May, 2030

Anticipated

Primary completion date

May, 2030

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Female

Age: 60+

Healthy Volunteers: Accepted

Mayo Clinic Rochester-

Inclusion Criteria:

  • Women who previously participated in this study
  • Currently aged 60 years and older
  • More than six months post chemotherapy or major surgery requiring general anesthesia
  • Willing and able to sign informed consent

Exclusion Criteria:

  • Not able to read and speak English
  • In hospice
  • Claustrophobic
  • If undergoing Tau imaging, cannot have QT Prolongation

Mayo Clinic Jacksonville-

Inclusion Criteria:

  • African American Women
  • Currently aged 60 years and older
  • More than six months post chemotherapy or major surgery requiring general anesthesia
  • Willing and able to sign informed consent

Exclusion Criteria:

  • Not able to read and speak English
  • In hospice
  • Claustrophobic
  • If undergoing Tau imaging, cannot have QT Prolongation

Study Design

Enrollment

614 participants

Anticipated

Intervention Model

Single group

Primary purpose

Diagnostic

Interventions and Outcome Measures

Arms

experimental: Women

18F-Flortaucipir and 11C-Pittsburgh compound-B radioligands will be used for experimental PET imaging of beta-amyloid and neurofibrillary tau pathology

Interventions

18-F-Flortaucipir

Radioligands for PET imaging of beta-amyloid and neurofibrillary tangle tau pathology

Primary outcome measure

  • 18F-Flortaucipir PET imaging [ Time Frame: 1 day ]
  • Pittsburgh compound-B PET imaging [ Time Frame: 1 day ]

Central Contacts and Locations

Central contacts

June Kendall-Thomas, CRC

507-293-9397kendallthomas.june15@mayo.edu

Desirae Howe-Clayton, CRC

507-255-0111howe.desirae@mayo.edu

Locations

Mayo Clinic

Recruiting

Jacksonville, Florida, United States, 32224

Contacts

Twilla Morrell, CRC

904-953-3420morrell.twila@mayo.edu

Ercilia Moncayo, CRC

904-953-3308moncayo.ercilia@mayo.edu

Principal Investigator:

Neill Graff-Radford, MD

More Information

Sponsor

Mayo Clinic

Last update posted

Nov 24, 2025

Last verified

Nov, 2025

Trial information was received from ClinicalTrials.gov and was last updated on 2026-10-10. This information was provided to ClinicalTrials.gov by Mayo Clinic on 2025-11-24. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.