Observational StudyLong Term Follow-Up of Patients With Mesothelioma and Individuals With Germline Mutations in BAP1

• Inclusion Criteria for Genetic Testing:

Cohort 1:

• Participant with pathology confirming a diagnosis of mesothelioma.
• Participant must have a deleterious germline BAP1 mutation. Results from either research or clinical analyses are sufficient for this criterion.

OR

• Participant with mesothelioma otherwise eligible for genetic testing in Cohort 2
• Age >= 2 years

Cohort 2:

-Individual with a germline BAP1 mutation who does not have a history of mesothelioma (other cancers are allowed). Results from either research or clinical analyses are sufficient for this criterion.

OR

-Individual with no history of mesothelioma with:

--A biological first degree relative (living or deceased) with a history of mesothelioma

OR

--A first degree biological relative with a CLIA (or equivalent) confirmed germline mutation in BAP1

OR

--A second degree biological relative with a CLIA (or equivalent) confirmed germline mutation in BAP1 if relevant first degree relative is deceased or unavailable for testing,

OR

--A second degree biological relative with mesothelioma and a CLIA (or equivalent) confirmed germline mutation in BAP1

-Age >= 2 years

All participants must understand and be willing to sign a written informed consent

Exclusion Criteria for Genetic Testing

None

Inclusion Criteria for Surveillance:

Inclusion Criteria for Surveillance

• Genetic testing criteria including age restrictions for respective cohorts must be met.
• Participants in Cohort 1 may be enrolled with positive results for germline BAP1 mutation regardless of CLIA (or equivalent) confirmation
• Participants in Cohort 2:

• must have CLIA (or equivalent) confirmed germline BAP1 mutation

Exclusion Criteria for Surveillance

None