Recruiting

Visual Remapping

Sponsor:

University of Minnesota

Code:

NCT03848663

Conditions

Age-related Macular Degeneration

Eligibility Criteria

Sex: All

Age: 16+

Healthy Volunteers: Accepted

Interventions

Traditional Remapping

Personalized Remapping

Study Details

Brief summary:

Reading performance in patients with Central Vision Loss and age matched controls with artificial scotomas will be measured with and without different kinds of remapping of missing text to different parts of the visual field.

Conditions

Age-related Macular Degeneration

Study ID

NCT03848663

Start date

Feb 1, 2022

Status verified date

Jul, 2026

Completion date

Nov 1, 2026

Anticipated

Primary completion date

Nov 1, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 16+

Healthy Volunteers: Accepted

Inclusion Criteria:

1. 16 years or older
2. Central vision loss of at least 5 deg diameter, including the fovea, from bilateral central scotomas
3. Stable fixation (+/- 1 deg) using their PRL.
4. No cognitive impairment as indicated by a Mini-Mental State Examination (MMSE).
5. Satisfactory calibration achievable using eye tracker

Exclusion Criteria:

1. Central vision loss of less than 5 deg diameter; scotomas that do not cover the fovea; unilateral scotomas
2. Poor fixation (worse than+/- 1 deg) using their PRL.
3. Cognitive impairment as indicated by a Mini-Mental State Examination (MMSE).
4. Satisfactory calibration not achievable using eye tracker

Study Design

Enrollment

108 participants

Anticipated

Allocation

Non randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Patients with scotoma

No remapping (control condition), traditional remapping, personalized remapping

active comparator: Normally sighted with artificial scotoma

No remapping (control condition), traditional remapping, personalized remapping

Interventions

Traditional Remapping

Shifting text outside of scotoma

Personalized Remapping

Shifting text based on individual letter-based perimetry

Primary outcome measure

  • Reading Speed for Individual Words [ Time Frame: Measured during third visit- each visit is one day only and this measure refers to data gathered during a < 1 hr long reading session during that day ]
  • Reading Speed for Sentences [ Time Frame: Measured during fourth visit- each visit is one day only and this measure refers to data gathered during a < 1 hr long reading session during that day ]
  • Reading Speed for Natural Text Samples [ Time Frame: Measured during fifth visit; each visit is one day only and this measure refers to data gathered during a < 1 hr long reading session during that day ]
  • Reading error rate for Individual Words [ Time Frame: Measured during third visit; each visit is one day only and this measure refers to data gathered during a < 1 hr long reading session during that day ]
  • Reading error rate for Sentences [ Time Frame: Measured during fourth visit; each visit is one day only and this measure refers to data gathered during a < 1 hr long reading session during that day ]
  • Reading error rate for Natural Text Samples [ Time Frame: Measured during fifth visit; each visit is one day only and this measure refers to data gathered during a < 1 hr long reading session during that day ]

Central Contacts and Locations

Central contacts

Stephen Engel, Ph.D.

612-625-5571engel@umn.edu

Gordon Legge, Ph.D.

legge@umn.edu

Locations

University of Minnesota

Recruiting

Minneapolis, Minnesota, United States, 55455

More Information

Sponsor

University of Minnesota

Last update posted

Jul 8, 2026

Last verified

Jul, 2026

Keywords

  • Scotoma
  • Remapping
  • Reading
  • Low vision
  • Visual aid

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Minnesota on 2026-07-08.