Recruiting

1 cm vs. 2 cm

Sponsor:

Melanoma and Skin Cancer Trials Limited

Code:

NCT03860883

Conditions

Cutaneous Melanoma, Stage II

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Wide Local Excision = 1cm Margin

Wide Local Excision = 2cm Margin

Study Details

Brief summary:

Patients with a primary invasive melanoma are recommended to undergo excision of the primary lesion with a wide margin. There is evidence that less radical margins of excision may be just as safe. This is a randomised controlled trial of 1 cm versus 2 cm margin of excision of the primary lesion for adult patients with stage II primary invasive cutaneous melanomas (AJCC 8th edition) to determine differences in disease-free survival. A reduction in margins is expected to improve patient quality of life.

Conditions

Cutaneous Melanoma, Stage II

Study ID

NCT03860883

Start date

Dec 17, 2019

Status verified date

Nov, 2024

Completion date

Dec 31, 2034

Anticipated

Primary completion date

Dec 31, 2029

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

Patients may be included in the study if they meet ALL of the following criteria:

1. 1. Patients must have a Stage II primary invasive cutaneous melanoma (pT2b-pT4b, AJCC 8th edition) with Breslow thickness >1.0mm to 2.0mm; >2.0mm to 4.0mm or >4.0mm with ulceration, or >2.0mm to 4.0mm; or >4.0mm without ulceration (Table 1) as determined by diagnostic biopsy (narrow excision, incision, shave or punch biopsy) and subsequent histopathological analysis.
2. Must have a primary melanoma that is cutaneous (including head, neck, trunk, extremity, scalp, palm or sole).
3. An uninterrupted 2cm margin must be technically feasible around biopsy scar or primary melanoma.
4. 4. Surgical intervention (which refers to the staging -SLNB and WLE as these are both to be done on the same day) must be completed within 120 days of the original diagnosis. Surgical intervention must also be performed within 28 days of randomisation.
5. Patients must be 18 years or older at time of consent.
6. Patient must be able to give informed consent and comply with the treatment protocol and follow up plan.
7. Life expectancy of at least 5 years from the time of diagnosis, not considering the melanoma in question, as determined by the PI.
8. Patients must have an ECOG performance score between 0 and 1 at screening.
9. A survivor of prior cancer is eligible provided that ALL of the following criteria are met and documented:

  • The patient has undergone potentially curative therapy for all prior malignancies,
  • There has been no evidence of recurrence of any prior malignancies for at least FIVE years (with the exception of successfully treated uterine/cervical or non-melanoma skin cancers (SCCs/BCCs) with no evidence of recurrence), and
  • The patient is deemed by their treating physician to be at low risk of recurrence from previous malignancies.

Exclusion Criteria:

Patients will be excluded from the study for ANY of the following reasons:

1. Uncertain diagnosis of melanoma i.e., so-called 'melanocytic lesion of unknown malignant potential'.
2. Patient has already undergone WLE at the site of the primary index lesion.
3. Patient unable or ineligible to undergo staging SLNB of the primary index lesion.
4. Perineural invasion or neurotropic melanoma: Neurotropism or perineural invasion in any type of melanoma is an exclusion. Perineural invasion does not include entrapment of nerves within the main primary tumour mass.
5. Desmoplastic melanoma: with any patient where pathology determines melanoma as PURE desmoplastic (as per WHO definition of >90% desmoplasia), they are not eligible for this study. However melanomas with less than 90% desmoplasia or mixed desmoplastic subtypes are eligible unless there is neurotropism present (perineural invasion).
6. Microsatellitosis (a nest of metastatic tumour cells found to be growing away from the primary tumour) as per AJCC 8th edition definition is an exclusion.
7. Subungual melanoma
8. Patient has already undergone a local flap reconstruction of the defect after excision of the primary and determination of an accurate excision margin is impossible.
9. History of previous or concurrent (i.e. >1 primary melanoma) invasive melanoma.
10. Melanoma located distal to the metacarpophalangeal joint; on the tip of the nose; the eyelids or on the ear; genitalia, perineum or anus; mucous membranes or internal viscera.
11. Physical, clinical, radiographic or pathologic evidence of satellite, in-transit, regional, or distant metastatic melanoma.
12. Patient has undergone surgery on a separate occasion to clear the lymph nodes of the probable draining lymphatic field, including -SLNB, of the index melanoma.
13. Any additional solid tumour or hematologic malignancy during the past 5 years (with exception of non- melanoma skin cancers (T1 skin lesions of squamous cell carcinoma (SCCs), basal cell carcinoma (BCCs)), or uterine/cervical cancer).
14. Melanoma-related operative procedures not corresponding to criteria described in the protocol.
15. Planned adjuvant radiotherapy to the primary melanoma site after wide local excision is not permitted as part of the protocol and any patients given this treatment would be excluded from the study.
16. History of organ transplantation.
17. Oral or parenteral immunosuppressive agents (not topical or inhaled steroids) at enrolment or within 6 months prior to enrolment.

Pregnancy is not a specific exclusion criterion for this trial, though it may not be clinically appropriate to perform a wide excision and SLNB until the pregnancy has been completed, which may exclude the patient due to violation of inclusion criterion 4. We would advise careful counselling of the patient prior to enrolling the patient, which would include a discussion at the treating centre's multidisciplinary team meeting or tumour board. We would strongly advise contacting the central trial office to discuss the case prior to enrolling on the study.

Study Design

Enrollment

2998 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Arm A (Wide Local Excision = 1cm Margin)

1cm Wide Local Excision margin + Sentinel Lymph Node Biopsy +/- Reconstruction

active comparator: Arm B (Wide Local Excision = 2cm Margin)

2 cm Wide Local Excision margin + Sentinel Lymph Node Biopsy +/- Reconstruction

Interventions

Wide Local Excision = 1cm Margin

A wide local excision involves removing an extra "safety margin" of skin surrounding the original melanoma site, to ensure that any remaining scattered melanoma tumour cells that may have been left behind after the first initial biopsy/surgery are removed.

Wide Local Excision = 2cm Margin

A wide local excision involves removing an extra "safety margin" of skin surrounding the original melanoma site, to ensure that any remaining scattered melanoma tumour cells that may have been left behind after the first initial biopsy/surgery are removed.

Primary outcome measure

  • Disease-Free Survival [ Time Frame: 0-60 months ]

Central Contacts and Locations

Central contacts

Melanoma and Skin Cancer Trials Coordinator

+61 3 9903 9022melmart@masc.org.au

Locations

University of South Alabama Mitchell Cancer Institute

Recruiting

Mobile, Alabama, United States, 36604

Contacts

John H Howard, MD

jhoward@health.southalabama.edu

Tiffany Fulford

tfulford@health.southalabama.edu

Principal Investigator:

John H Howard, MD

Banner MD Anderson Cancer Center

Recruiting

Gilbert, Arizona, United States, 85234

Contacts

Mark Gimbel

mark.gimbel@bannerhealth.com

Sandra Ortega

sandra.ortega@bannerhealth.com

Principal Investigator:

Mark Gimbel

Mayo Clinic Phoenix

Recruiting

Phoenix, Arizona, United States, 85054

Contacts

Barbara A Pockaj, MD

pockaj.barbara@mayo.edu

Courtney Nelson

Nelson.Courtney4@mayo.edu

University of Arkansas for Medical Sciences

Recruiting

Little Rock, Arkansas, United States, 72205

Contacts

Michail Mavros

MMavros@uams.edu

Principal Investigator:

Michail Mavros

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care

Recruiting

Irvine, California, United States, 92868

Principal Investigator:

Maki Yamamoto, MD

Los Angeles General Medical Center

Recruiting

Los Angeles, California, United States, 90033

Contacts

Gino In

gino.in@med.usc.edu

Principal Investigator:

Gino In

Los Angeles General Medical Center

Recruiting

Los Angeles, California, United States, 90033

Contacts

Gino In, MD

gino.in@med.usc.edu

Principal Investigator:

Gino In, MD

USC Norris Comprehensive Cancer Center

Recruiting

Los Angeles, California, United States, 90033

Contacts

Gino In

gino.in@med.usc.edu

Principal Investigator:

Gino In

USC Norris Comprehensive Cancer Center

Recruiting

Los Angeles, California, United States, 90033

Contacts

Gino In, MD

gino.in@med.usc.edu

Principal Investigator:

Gino In, MD

The Angeles (Cedars-Sinai Medical Center and its Affiliates)

Recruiting

Los Angeles, California, United States, 90048-1804

Principal Investigator:

Dr Mark Faries

UC Irvine Health - Chao Family Comprehensive Cancer Center

Recruiting

Orange, California, United States, 92868

Contacts

Jeremy Harris

jpharris1@hs.uci.edu

Principal Investigator:

Jeremy Harris

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care

Recruiting

Orange, California, United States, 92868

Contacts

Maki Yamamoto

myamamot@hs.uci.edu

Principal Investigator:

Maki Yamamoto

Stanford Cancer Institute

Recruiting

Palo Alto, California, United States, 94304

Contacts

Amanda Kirane, MD FACS

650-725-4169akirane@stanford.edu

Patrick Yuan

+1 650-498-7061yuanp@stanford.edu

Huntington Memorial Hospital

Recruiting

Pasadena, California, United States, 91105

Contacts

Mark Faries

mfaries@theangelesclinic.org

Principal Investigator:

Mark Faries

Stanford Cancer Center South Bay

Recruiting

San Jose, California, United States, 95124

Principal Investigator:

Amanda Kirane

Kaiser Permanente - Vallejo Medical Center

Recruiting

Vallejo, California, United States, 94589

Contacts

Tatjana Kolevska, MD

Tatjana.Kolevska@kp.org

Desiree Goldstein

desiree.goldstein@kp.org

Principal Investigator:

Tatjana Kolevska, MD

Kaiser Permanente - Walnut Creek Medical Center

Recruiting

Walnut Creek, California, United States, 94596

Contacts

Tatjana Kolevska, MD

Tatjana.Kolevska@kp.org

Desiree Goldstein

desiree.goldstein@kp.org

Principal Investigator:

Tatjana Kolevska, MD

Smilow Hospital Care Center, Guilford

Recruiting

Guilford, Connecticut, United States, 06437

Contacts

James Clune

james.clune@yale.edu

Principal Investigator:

James Clune

Yale University

Recruiting

New Haven, Connecticut, United States, 06520

Contacts

James Clune

james.clune@yale.edu

Principal Investigator:

James Clune

MedStar Georgetown University Hospital

Recruiting

Washington, District of Columbia, United States, 20007

Contacts

Geoffrey T Gibney

geofrey.t.gibney@gunet.georgetown.edu

Principal Investigator:

Geoffrey T Gibney

MedStar Washington Hospital Center

Recruiting

Washington, District of Columbia, United States, 20010

Contacts

Marc Boisvert, MD

Marc.E.Boisvert@medstar.net

Nicolas Rojas

Nicolas.Rojas@medstar.net

Principal Investigator:

Marc Boisvert, MD

University of Miami Sylvester Comprehensive Cancer Center at Aventura

Recruiting

Aventura, Florida, United States, 33180

Contacts

Jessica S Crystal

jxc2521@med.miami.edu

Principal Investigator:

Jessica S Crystal

University of Miami Sylvester Comprehensive Cancer Center at Coral Gables

Recruiting

Coral Gables, Florida, United States, 33146

Contacts

Jessica S Crystal

jxc2521@med.miami.edu

Principal Investigator:

Jessica S Crystal

University of Miami Sylvester Cancer Center at Coral Springs

Recruiting

Coral Springs, Florida, United States, 33065

Contacts

Jessica S Crystal

jxc2521@med.miami.edu

Principal Investigator:

Jessica S Crystal

University of Miami Sylvester Comprehensive Center at Deerfield Beach

Recruiting

Deerfield Beach, Florida, United States, 33442

Contacts

Jessica S Crystal

jxc2521@med.miami.edu

Principal Investigator:

Jessica S Crystal

University of Miami Sylvester Comprehensive Center at Hollywood

Recruiting

Hollywood, Florida, United States, 33021

Contacts

Jessica S Crystal

jxc2521@med.miami.edu

Principal Investigator:

Jessica S Crystal

Baptist MD Anderson Cancer Center

Recruiting

Jacksonville, Florida, United States, 32207

Contacts

Konstantinos Chouliaras

Konstantinos.Chouliaras@bmcjax.com

Principal Investigator:

Konstantinos Chouliaras

Mayo Clinic in Florida

Recruiting

Jacksonville, Florida, United States, 32224

Contacts

James W Jakub

Jakub.James@mayo.edu

Principal Investigator:

James W Jakub

Lakeland Regional Health Hollis Cancer Center

Recruiting

Lakeland, Florida, United States, 33805

Contacts

Manuel Molina

manuel.molina@mylrh.org

Principal Investigator:

Manuel Molina

University of Miami Miller School of Medicine-Sylvester Cancer Centre

Recruiting

Miami, Florida, United States, 33136

Contacts

Jessica S Crystal

jxc2521@med.miami.edu

Principal Investigator:

Jessica S Crystal

University of Miami Comprehensive Cancer Center at Kendall

Recruiting

Miami, Florida, United States, 33176

Contacts

Jessica S Crystal

jxc2521@med.miami.edu

Principal Investigator:

Jessica S Crystal

University of Miami Comprehensive Cancer Center at Plantation

Recruiting

Plantation, Florida, United States, 33324

Contacts

Jessica S Crystal

jxc2521@med.miami.edu

Principal Investigator:

Jessica S Crystal

Moffitt Cancer Center - McKinley Campus

Recruiting

Tampa, Florida, United States, 33612

Contacts

Jonathan Zager

Jonathan.zager@moffitt.org

Principal Investigator:

Jonathan Zager

Moffitt Cancer Center, Magnolia Campus

Recruiting

Tampa, Florida, United States, 33612

Contacts

Jonathan Zager

Jonathan.zager@moffitt.org

Principal Investigator:

Jonathan Zager

Emory University Hospital Midtown

Recruiting

Atlanta, Georgia, United States, 30308

Contacts

Michael Lowe, MD

mlowe3@emory.edu

Rachel Mock

rachel.ashley.mock@emory.edu

Principal Investigator:

Michael Lowe, MD

Emory University

Recruiting

Atlanta, Georgia, United States, 30322

Principal Investigator:

Dr Michael Lowe

Emory Saint Joseph's Hospital

Recruiting

Atlanta, Georgia, United States, 30342

Contacts

Michael Lowe, MD

mlowe3@emory.edu

Charisse Ellis

chariesse.aliyya.ellis@emory.edu

Principal Investigator:

Michael Lowe, MD

Northside Hospital Atlanta

Recruiting

Atlanta, Georgia, United States, 30342

Contacts

Nicole Kounalakis

nicole.kounalakis@northside.com

Principal Investigator:

Nicole Kounalakis

Nancy N and JC Lewis Cancer & Research Pavilion St. Joseph's/Candler

Recruiting

Savannah, Georgia, United States, 31405

Contacts

Yana Puckett, MD

drpucketty@sjchs.org

Stephanie Reyes

smiths1@sjchs.org

Principal Investigator:

Yana Puckett, MD

Advocate Illinois Masonic Medical Center

Recruiting

Chicago, Illinois, United States, 60657

Contacts

Sigrun Hallmeyer

sigrun.hallmeyer@aah.org

Principal Investigator:

Sigrun Hallmeyer

Northwestern Medicine Cancer Center Kishwaukee

Recruiting

DeKalb, Illinois, United States, 60115

Contacts

Jeffrey Wayne

jeffrey.wayne@nm.org

Principal Investigator:

Jeffrey Wayne

Northwestern University

Recruiting

Evanston, Illinois, United States, 60208

Contacts

Jeffrey Wayne

jeffrey.wayne@nm.org

Principal Investigator:

Jeffrey Wayne

Northwestern Medicine Cancer Center Delnor

Recruiting

Geneva, Illinois, United States, 60134

Contacts

Jeffrey Wayne

jeffrey.wayne@nm.org

Principal Investigator:

Jeffrey Wayne

Northwestern Medicine Cancer Center Lake Forest Hospital

Recruiting

Lake Forest, Illinois, United States, 60045

Contacts

Jeffrey Wayne

jeffrey.wayne@nm.org

Principal Investigator:

Jeffrey Wayne

Advocate Lutheran General Hospital

Recruiting

Park Ridge, Illinois, United States, 60068

Contacts

Sigrun Hallmeyer, MD

sigrun.hallmeyer@aah.org

Cheryl Korabik

cheryl.korabik@aah.org

Principal Investigator:

Sigrun Hallmeyer, MD

Northwestern Medicine Cancer Center Warrenville

Recruiting

Warrenville, Illinois, United States, 60555

Contacts

Jeffrey Wayne

jeffrey.wayne@nm.org

Principal Investigator:

Jeffrey Wayne

Indiana University - Melvin and Bren Simon Cancer Center

Recruiting

Indianapolis, Indiana, United States, 46202

Contacts

karlb@iu.edu

Principal Investigator:

Karl Bilimoria, MD

Indiana University Melvin and Bren Simon Comprehensive Cancer Center

Recruiting

Indianapolis, Indiana, United States, 46202

Contacts

Karl Bilimoria

karlb@iu.edu

Principal Investigator:

Karl Bilimoria

Franciscan Health Indianapolis

Recruiting

Indianapolis, Indiana, United States, 46237

Contacts

Juliana Meyer

juliana.meyer@franciscanalliance.org

Principal Investigator:

Juliana Meyer

University of Kansas Hospital - Indian Creek Campus

Recruiting

Overland Park, Kansas, United States, 66211

Contacts

Luke Selby

lselby@kumc.edu

Principal Investigator:

Luke Selby

University of Kansas Hospital- Westwood Cancer Center

Recruiting

Westwood, Kansas, United States, 66205

Contacts

Luke Selby

lselby@kumc.edu

Principal Investigator:

Luke Selby

University of Kentucky

Recruiting

Lexington, Kentucky, United States, 40506

Contacts

Erin Burke

erin.burke@uky.edu

Principal Investigator:

Erin Burke

MedStar Franklin Square Medical Center

Recruiting

Baltimore, Maryland, United States, 21237

Contacts

Edward McCarron

edward.mccarron@medstar.net

Principal Investigator:

Edward McCarron

University of Michigan Medical Center

Recruiting

Ann Arbor, Michigan, United States, 48109

Contacts

Christina Angeles

angelesc@med.umich.edu

Principal Investigator:

Christina Angeles

University of Michigan - Brighton Center for Specialty Care

Recruiting

Brighton, Michigan, United States, 48116

Contacts

Christina Angeles

angelesc@med.umich.edu

Principal Investigator:

Christina Angeles

Mercy Health Saint Mary's

Recruiting

Grand Rapids, Michigan, United States, 49503

Contacts

Kathleen Yost

kyost@crcwm.org

Renee Porter

renee.porter@crcwm.org

Principal Investigator:

Kathleen Yost

Spectrum Health at Butterworth Campus

Recruiting

Grand Rapids, Michigan, United States, 49503

Contacts

Kathleen Yost

Kyost@chcwm.com

Principal Investigator:

Kathleen Yost

West Michigan Cancer Centre

Recruiting

Kalamazoo, Michigan, United States, 49007

Contacts

Kathleen Yost

kyost@chcwm.com

Principal Investigator:

Kathleen Yost

Siteman Cancer Centre, Barnes Jewish West County

Recruiting

Creve Coeur, Missouri, United States, 63141

Contacts

Ryan Fields

rcfields@wustl.edu

Principal Investigator:

Ryan Fields

University of Kansas Cancer Center

Recruiting

Kansas City, Missouri, United States, 64154

Contacts

Luke Selby

lselby@kumc.edu

Principal Investigator:

Luke Selby

Washington University School of Medicine

Recruiting

Saint Louis, Missouri, United States, 63110

Contacts

Ryan Fields

rcfields@wustl.edu

Principal Investigator:

Ryan Fields

Cox South Hospital

Recruiting

Springfield, Missouri, United States, 65807

Principal Investigator:

Srikant Nannapaneni

Nebraska Medicine - Bellevue

Recruiting

Bellevue, Nebraska, United States, 68123

Contacts

Bradley Reames

bradley.reames@unmc.edu

Principal Investigator:

Bradley Reames

Nebraska Medicine-Village Pointe

Recruiting

Omaha, Nebraska, United States, 68118

Contacts

Bradley Reames

bradley.reames@unmc.edu

Principal Investigator:

Bradley Reames

University of Nebraska Medicine

Recruiting

Omaha, Nebraska, United States, 68198

Contacts

Bradley Reames

bradley.reames@unmc.edu

Principal Investigator:

Bradley Reames

Cooperman Barnabas Medical Center

Recruiting

Livingston, New Jersey, United States, 07039

Contacts

Adam Berger

ab2047@cinj.rutgers.edu

Principal Investigator:

Adam Berger

Rutgers Cancer Institute of New Jersey

Recruiting

Piscataway, New Jersey, United States, 08854

Principal Investigator:

Professor Adam Berger

Lovelace Medical Centre-Saint Joseph Square

Recruiting

Albuquerque, New Mexico, United States, 87110

Contacts

Bridget Fahy, MD

BFahy@salud.unm.edu

Lovelace Women's Hospital

Recruiting

Albuquerque, New Mexico, United States, 87110

Contacts

Bridget Fahy, MD

BFahy@salud.unm.edu

Principal Investigator:

Bridget Fahy, MD

Northwell Health Imbert Cancer Center

Recruiting

Bay Shore, New York, United States, 11706

Contacts

Alan Kadison, MD

akadison@northwell.edu

Diane Delliliune

DDellili@northwell.edu

Principal Investigator:

Alan Kadison, MD

Roswell Park Cancer Institute

Recruiting

Buffalo, New York, United States, 14203

Contacts

Shalana O'Brien

shalana.obrien@roswellpark.org

Principal Investigator:

Shalana O'Brien

Northwell Health/Center for Advanced Medicine

Recruiting

Lake Success, New York, United States, 11042

Contacts

Alan Kadison, MD

akadison@northwell.edu

Alexa Amoroso

aamoroso1@northwell.edu

Principal Investigator:

Alan Kadison, MD

NYU Langone Medical Center (Winthrop Hospital)

Recruiting

Mineola, New York, United States, 11501

Contacts

Erica Friedman

mailto:Erica.Friedman@nyulangone.org

Principal Investigator:

Erica Friedman

Northern Westchester Hospital

Recruiting

Mount Kisco, New York, United States, 10549

Contacts

Alan Kadison

Akadison@northwell.edu

Principal Investigator:

Alan Kadison

Laura & Isaac Perlmutter Cancer Center at NYU Langone Health

Recruiting

New York, New York, United States, 10016

Contacts

Erica Friedman

mailto:Erica.Friedman@nyulangone.org

Principal Investigator:

Erica Friedman

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

Recruiting

New York, New York, United States, 10032

Contacts

Bret Taback

bt2160@cumc.columbia.ed

Principal Investigator:

Bret Taback

Memorial Sloan Kettering Cancer Center

Recruiting

New York, New York, United States, 10065

Principal Investigator:

Associate Professor Danielle Bello

Vassar Brothers Medical Center

Recruiting

Poughkeepsie, New York, United States, 12601

Contacts

James Nitzkorski

james.nitzkorski@nuvancehealth.org

Karley Flinn

Jameskarley.flinn@nuvancehealth.org

Principal Investigator:

James Nitzkorski

University of Rochester

Recruiting

Rochester, New York, United States, 14642

Contacts

Paul Barr

paul_barr@urmc.rochester.edu

Principal Investigator:

Paul Barr

Phelps Memorial Hospital Center

Recruiting

Sleepy Hollow, New York, United States, 10591

Contacts

Alan Kadison

akadison@northwell.edu

Principal Investigator:

Alan Kadison

State University of New York Upstate Medical University

Recruiting

Syracuse, New York, United States, 13210

Contacts

Daniel Thomas, MD

ThomasDa@upstate.edu

Laine Abernathy

abernatl@upstate.edu

Principal Investigator:

Daniel Thomas, MD

State University of New York Upstate Medical Center-Community Campus

Recruiting

Syracuse, New York, United States, 13215

Contacts

Daniel Thomas, MD

ThomasDa@upstate.edu

Laine Abernathy

abernatl@upstate.edu

Principal Investigator:

Daniel Thomas, MD

Wilmont Cancer Institute at Webster

Recruiting

Webster, New York, United States, 14580

Contacts

Paul Barr, MD

paul_barr@urmc.rochester.edu

Sarah Cawley

sarah_cawley@urmc.rochester.edu

Principal Investigator:

Paul Barr, MD

University of North Carolina at Chapel Hill

Recruiting

Chapel Hill, North Carolina, United States, 27599

Contacts

David W Ollila

david_ollila@med.unc.edu

Principal Investigator:

David W Ollila

Duke University Medical Center

Recruiting

Durham, North Carolina, United States, 27710

Contacts

Jay Lee

jay.lee@duke.edu

Principal Investigator:

Jay Lee

East Carolina University

Recruiting

Greenville, North Carolina, United States, 27858

Contacts

Nasreen Vohra

joynersu@ecu.edu

Principal Investigator:

Nasreen Vohra

University of North Carolina Hospitals - Hillsborough Campus

Recruiting

Hillsborough, North Carolina, United States, 27278

Contacts

David Ollila

david_ollila@med.unc.edu

Principal Investigator:

David Ollila

Sanford Broadway Medical Centre

Recruiting

Fargo, North Dakota, United States, 58102

Contacts

Preston Steen

preston.steen@sanfordhealth.org

Principal Investigator:

Preston Steen

Sanford Roger Maris Cancer Centre

Recruiting

Fargo, North Dakota, United States, 58102

Contacts

Preston Steen

preston.steen@sanfordhealth.org

Principal Investigator:

Preston Steen

University Hospitals Avon Health Center

Recruiting

Avon, Ohio, United States, 44011

Contacts

Luke Rothermel

Luke.Rothermel@UHhospitals.org

Principal Investigator:

Luke Rothermel

Miami Valley Hospital South

Recruiting

Centerville, Ohio, United States, 45459

Contacts

James Ouellette

jrouellett@premierhealth.com

Principal Investigator:

James Ouellette

University Hospitals Geauga Medical Center

Recruiting

Chardon, Ohio, United States, 44024

Contacts

Luke Rothermel

Luke.Rothermel@UHhospitals.org

Principal Investigator:

Luke Rothermel

University of Cincinnati

Recruiting

Cincinnati, Ohio, United States, 45219

Contacts

Jeffrey Sussman

sussmaj@ucmail.uc.edu

Principal Investigator:

Jeffrey Sussman

University Hospitals Cleveland Medical Centre

Recruiting

Cleveland, Ohio, United States, 44106

Contacts

Luke Rothermel

Luke.Rothermel@UHhospitals.org

Principal Investigator:

Luke Rothermel

Ohio State University Comprehensive Cancer Center

Recruiting

Columbus, Ohio, United States, 43210

Contacts

Joal Joal

Joal.Beane@osumc.edu

Principal Investigator:

Joal Joal

University Hospitals Chagrin Highlands Medical Centre

Recruiting

Orange Village, Ohio, United States, 44122

Contacts

Luke Rothermel

Luke.Rothermel@UHhospitals.org

Principal Investigator:

Luke Rothermel

West Chester Hospital (OH394)

Recruiting

West Chester, Ohio, United States, 45069

Contacts

Jeffrey Sussman

sussmaj@ucmail.uc.edu

Principal Investigator:

Jeffrey Sussman

University Hospitals St. John Medical Center

Recruiting

Westlake, Ohio, United States, 44145

Contacts

Luke Rothermel

Luke.Rothermel@UHhospitals.org

Principal Investigator:

Luke Rothermel

OUHSC Stephenson Cancer Center

Recruiting

Oklahoma City, Oklahoma, United States, 73104

Contacts

William Dooley

William-Dooley@ouhsc.edu

Principal Investigator:

William Dooley

Mercy Health Center - Oncology Hematology

Recruiting

Oklahoma City, Oklahoma, United States, 73120-8362

Contacts

Christian Ellis, DO

christian.ellis@mercy.net

Trisha Strubhar

trisha.strubhar@mercy.net

Principal Investigator:

Christian Ellis, DO

Kaiser Sunnyside Medical Center

Recruiting

Clackamas, Oregon, United States, 97015

Contacts

Sandeep Mashru

sandeep.h.mashru@kp.org

Principal Investigator:

Sandeep Mashru

Kaiser Permanente Northwest - Oncology Clinic

Recruiting

Portland, Oregon, United States, 97227

Contacts

Sandeep Mashru

sandeep.h.mashru@kp.org

Principal Investigator:

Sandeep Mashru

St. Luke's University Health Network - Allentown Cancer Center

Recruiting

Allentown, Pennsylvania, United States, 18104

Contacts

Darius Desai, MD

Darius.Desai@sluhn.org

Amy Grossman

Amy.Grossman@sluhn.org

Principal Investigator:

Darius Desai, MD

St Luke's University Health Network, Bethlehem Campus

Recruiting

Bethlehem, Pennsylvania, United States, 18015

Contacts

Darius Desai

Darius.Desai@sluhn.org

Principal Investigator:

Darius Desai

St Luke's University Health Network, Anderson Campus

Recruiting

Easton, Pennsylvania, United States, 18045

Contacts

Darius Desai

Darius.Desai@sluhn.org

Principal Investigator:

Darius Desai

Fox Chase Cancer Center

Recruiting

Philadelphia, Pennsylvania, United States, 19111

Principal Investigator:

Dr Stephanie Greco

St Luke's University Health Network Quakertown Campus

Recruiting

Quakertown, Pennsylvania, United States, 18951

Contacts

Darius Desai

Darius.Desai@sluhn.org

Principal Investigator:

Darius Desai

St. Luke's University Health Network - Upper Bucks

Recruiting

Quakertown, Pennsylvania, United States, 18951

Contacts

Darius Desai, MD

Darius.Desai@sluhn.org

Amy Grossman

Amy.Grossman@sluhn.org

Principal Investigator:

Darius Desai, MD

Guthrie Medical Group PC-Robert Packer Hospital

Recruiting

Sayre, Pennsylvania, United States, 18840

Contacts

David Bertsch, MD

david.j.bertsch@guthrie.org

Susan Hadlock

susan.hadlock@guthrie.org

Principal Investigator:

David Bertsch, MD

Medical University of South Carolina

Recruiting

Charleston, South Carolina, United States, 29425

Contacts

Andrea Abbott

abbottan@musc.edu

Principal Investigator:

Andrea Abbott

Sanford Cancer Center Oncology Clinic

Recruiting

Sioux Falls, South Dakota, United States, 57105,

Contacts

Daniel Almquist, MD

daniel.almquist@sanfordhealth.org

Principal Investigator:

Daniel Almquist, MD

Sanford USD Medical Center - Sioux Falls

Recruiting

Sioux Falls, South Dakota, United States, 57105,

Contacts

Daniel Almquist, MD

daniel.almquist@sanfordhealth.org

Principal Investigator:

Daniel Almquist, MD

The University of Texas MD Anderson Cancer Center

Recruiting

Houston, Texas, United States, 77030

Contacts

Jeffrey Gershenwald

jgershen@mdanderson.org

Principal Investigator:

Jeffrey Gershenwald

University of Texas Health Science Center at San Antonio

Recruiting

San Antonio, Texas, United States, 78284-7884

Contacts

Fedrico Tozzi, MD

tozzi@uthscsa.edu

Samantha Bankston

bankstonsm@uthscsa.edu

Principal Investigator:

Fedrico Tozzi, MD

Intermountain Medical Center

Recruiting

Murray, Utah, United States, 84157

Contacts

Tawnya Bowles

tawnya.bowles@imail.org

Kevin Adams

Kevin.Adams@imail.org

Principal Investigator:

Tawnya Bowles

Huntsman Cancer Institute (The University of Utah)

Recruiting

Salt Lake City, Utah, United States, 84112

Principal Investigator:

Professor John Hynstrom

University of Vermont Medical Center

Recruiting

Burlington, Vermont, United States, 05401

Contacts

Jessica Cintolo-Gonzalez, MD

jessica.cintolo-gonzalez@uvmhealth.org

Elizabeth Abrecht

elizabeth.abrecht@uvmhealth.org

University of Vermount and Sate Agricultural College

Recruiting

Burlington, Vermont, United States, 05405

Contacts

Jessica Cintolo-Gonzalez, MD

jessica.cintolo-gonzalez@uvmhealth.org

Elizabeth Abrecht

elizabeth.abrecht@uvmhealth.org

University of Virginia Health System

Recruiting

Charlottesville, Virginia, United States, 22903

Contacts

Lynn Dengel

LTD5B@uvahealth.org

Principal Investigator:

Lynn Dengel

VCU Massey Cancer Center Peninsula Cancer Institute

Recruiting

Newport News, Virginia, United States, 23601

Contacts

Giao Phan

giao.phan@vcuhealth.org

Principal Investigator:

Giao Phan

VCU Massey Cancer Center

Recruiting

Richmond, Virginia, United States, 23298

Contacts

Giao Phan

giao.phan@vcuhealth.org

Principal Investigator:

Giao Phan

Carilion Roanoke Memorial Hospital

Recruiting

Roanoke, Virginia, United States, 24014

Contacts

Giao Phan

giao.phan@vcuhealth.org

Kristin Campbell

klcampbell@vcu.edu

Principal Investigator:

Giao Phan

VCU Massey Cancer Center Affiliate Valley Health

Recruiting

Winchester, Virginia, United States, 22601

Contacts

Giao Phan

giao.phan@vcuhealth.org

Principal Investigator:

Giao Phan

University of Winsconsin Carbone Cancer Center-Eastpark medical Center

Recruiting

Madison, Wisconsin, United States, 53718

Contacts

Heather Neuman

neuman@surgery.wisc.edu

Heather Neuman, MD

neuman@surgery.wisc.edu

Principal Investigator:

Heather Neuman, MD

University of Wisconsin Carbone Cancer Center

Recruiting

Madison, Wisconsin, United States, 53792

Contacts

Heather Neuman

neuman@surgery.wisc.edu

Sam Hanson

shhanson@wisc.ed

Principal Investigator:

Heather Neuman

Marshfield Medical Center - Marshfield

Recruiting

Marshfield, Wisconsin, United States, 54449

Contacts

Rohit Sharma

sharma.rohit@marshfieldclinic.org

Principal Investigator:

Rohit Sharma

Aurora St Luke's Medical Center

Recruiting

Milwaukee, Wisconsin, United States, 53215

Contacts

Sigrun Hallmeyer

sigrun.hallmeyer@aah.org

Principal Investigator:

Sigrun Hallmeyer

Medical College of Wisconsin

Recruiting

Milwaukee, Wisconsin, United States, 53226

Contacts

Jennifer Bruening

jbruening@mcw.edu

Chloe Papageorgio

cpapageorgio@mcw.edu

Principal Investigator:

Jennifer Bruening

Marshfield Medical Center- Weston

Recruiting

Weston, Wisconsin, United States, 54476

Contacts

Rohit Sharma, MD

sharma.rohit@marshfieldclinic.org

Principal Investigator:

Rohit Sharma, sharma.rohit@marshfieldclinic.

Tom Baker Cancer Centre

Recruiting

Calgary, Alberta, Canada, T2N 4N2

BCCA - Cancer Centre for the Southern Interior

Recruiting

Kelowna, British Columbia, Canada, V1Y 5L3

Contacts

Christopher Baliski

cbaliski@bccancer.bc.ca

Principal Investigator:

Christopher Baliski

CancerCare Manitoba

Recruiting

Winnipeg, Manitoba, Canada, R3E 0V9

Contacts

Justin Rivard, Dr

204-787-4156

Royal Victoria Regional Health Centre

Recruiting

Barrie, Ontario, Canada, L4M 6M2

Contacts

Kelly Cruise

705-728-9090cruisek@rvh.on.ca

Principal Investigator:

Dr. Renee Hanrahan

Hamilton Health Sciences Centre

Recruiting

Hamilton, Ontario, Canada, L8V 1C3

Contacts

Dr. Valerie Francescutti

905-387-9495

Principal Investigator:

Dr. Valerie Francescutti

Oak Valley Health

Recruiting

Markham, Ontario, Canada, L3P 7P3

Contacts

Jennifer Zhirui Li

enli@oakvalleyhealth.ca

Principal Investigator:

Jennifer Zhirui Li

Ottawa Hospital Research Institute

Recruiting

Ottawa, Ontario, Canada, K1Y 4E9

Contacts

Dr. Carolyn Nessim

cnessim@toh.ca

Principal Investigator:

Dr. Carolyn Nessim

Sunnybrook Health Sciences Centre

Recruiting

Toronto, Ontario, Canada, M4N 3M5

Contacts

Dr Frances Wright

416-480-4210

Principal Investigator:

Dr Frances Wright

UHN - Princess Margaret Cancer Centre

Recruiting

Toronto, Ontario, Canada, M5G 2C1

Contacts

Alexandra Easson, Dr

Alexandra.Easson@uhn.ca

Hopital Maisonneuve-Rosemont

Recruiting

Montreal, Quebec, Canada, H1T 2M4

Contacts

Audrey Lamoureux

514-252-3400

Leïla Idrissi Kaïtouni

514-252-3400

Principal Investigator:

Dr. Mai-Kim Gervais

Centre Hospitalier de l'Universite de Montreal (CHUM)

Recruiting

Montréal, Quebec, Canada, H2X 3E4

Principal Investigator:

Kerianna Boulva

Hotel-Dieu de Quebec

Recruiting

Québec City, Quebec, Canada, G1R2J6

Contacts

Dr Cindy Boulanger-Gobeil

cindy.boulanger-gobeil@chudequebec.ca

Principal Investigator:

Dr Cindy Boulanger-Gobeil

More Information

Sponsor

Melanoma and Skin Cancer Trials Limited

Last update posted

Nov 27, 2024

Last verified

Nov, 2024

Keywords

  • Malignant
  • Melanoma
  • Cancer
  • Surgery

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by Melanoma and Skin Cancer Trials Limited on 2024-11-27.