Recruiting

Endocrine Conditions

Sponsor:

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Code:

NCT03867448

Conditions

Endocrine Disease

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Interventions

Creation of side holes in catheters for adrenal vein sampling

Study Details

Brief summary:

Background:

Endocrine disorders involve changes to glands that produce hormones. Hormones are released by these glands into the blood so they can direct the function of other tissues in the body. Researchers want to study people who may have endocrine disorders. They want to learn more about the conditions that affect endocrine glands.

Objective:

To study adults with a variety of endocrine disorders for research and physician education.

Eligibility:

Adults ages 18 and older who have an endocrine or metabolic-related disorder

Healthy volunteers 18 and older

Design:

Participants will be screened with a review of their medical records.

Participants will have a physical exam and medical history.

The length of the study and the schedule will vary by participant. Tests may include:

Blood and urine tests

Stool and saliva samples

Imaging studies: Participants will lie on a table while a machine takes pictures of the body. They may be injected with a substance to make their organs more visible in the pictures.

Tests of endocrine tissue function

Consultation with other specialists

Sleep study

Medical photographs

Participants may be treated for their endocrine disorder. This could include:

Surgery. If tissue is removed during surgery, it may be studied.

Radiation

Medicine

Participants may have genetic testing. This will be done with a small amount of blood, cells from a cheek swab, or saliva.

Sponsoring Institution: National Institute of Digestive, Diabetes and Kidney Disease

...

Conditions

Endocrine Disease

Study ID

NCT03867448

Start date

Mar 27, 2019

Status verified date

Sep 3, 2026

Completion date

Jan 1, 2036

Anticipated

Primary completion date

Jan 1, 2036

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

  • INCLUSION CRITERIA:

In order to be eligible to participate in this study, an individual must meet all the following criteria:

  • Adult men and women age 18 years or older.
  • Known or suspected endocrine disorders requiring clinical screening, management and/or treatment and follow-up.
  • Stated willingness to comply with all study procedures and availability for the duration of the study

EXCLUSION CRITERIA:

  • Unstable participants and participants with severe organ failure, or those with a condition or medical treatment that may affect/limit the endocrine work-up and exhaust Clinical Center, IETP resources will be excluded if appropriate.
  • Inability of a subject to adhere to a proposed schedule of visits.
  • Inability to provide informed consent.

Study Design

Enrollment

1000 participants

Anticipated

Interventions and Outcome Measures

Arms

Adults with Endocrine Disorder

Adults referred to NIH with possible endocrine conditions

Adults with hyperaldosteronism

Adults referred to NIH or studied at NIH and determined to have hyperaldosteronism

Interventions

Creation of side holes in catheters for adrenal vein sampling

one or two side-holes will be created by the interventional radiologist to facilitate adrenal vein sampling

Primary outcome measure

  • Diagnosis/Treatment [ Time Frame: variable ]

Central Contacts and Locations

Central contacts

Raven N McGlotten, R.N.

(301) 827-0190mcglottenr@mail.nih.gov

Lynnette K Nieman, M.D.

(301) 496-8935niemanl@mail.nih.gov

Locations

National Institutes of Health Clinical Center

Recruiting

Bethesda, Maryland, United States, 20892

Contacts

For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)

800-411-1222prpl@cc.nih.gov

More Information

Sponsor

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Last update posted

Sep 8, 2026

Last verified

Sep 3, 2026

Keywords

  • Adrenal Gland
  • Pituitary
  • Natural History

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) on 2026-09-08.